en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">This study investigated the relationship between histomorphological changes and electrical resistance in liver tissue following radiation exposure in a rat model. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Five-week-old Sprague&ndash;Dawley rats were exposed to ionizing radiation at doses of 1, 5, 10, and 20 Gy. Impedance changes were measured using alternating current (AC) frequencies ranging from 1 kHz to 1 MHz. Gross physical signs were monitored four days post-irradiation. Transmission electron microscopy (TEM) was employed to assess histological alterations in liver tissue. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">As the radiation dose increased, notable gross changes in general signs were observed. Impedance characteristics varied according to dose, reflecting underlying histological alterations. Ultrastructural examination revealed damage to intracellular organelles, likely resulting from disrupted mitotic activity in irradiated liver tissue. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Radiation exposure induces dose-dependent histomorphological changes and corresponding alterations in electrical impedance in rat liver tissue. These findings provide insights into the relationship between tissue structure and bioelectrical properties under radiation stress.</span></span></span></span></span></span></span></span></span></span></div> Electric impedance, radiation effects, liver, microscopy electron transmission. 521 526 http://ijrr.com/browse.php?a_code=A-10-1-1528&slc_lang=en&sid=1 S.K. Sung 7900319475328460033665 7900319475328460033665 No Department of Neurosurgery, School of Medicine, Pusan National University, Yang-san, Korea G.R. Kim 7900319475328460033666 7900319475328460033666 No Department of Neurosurgery, Pusan National University Yang-san Hospital, Yangsan, Korea M.S. Lee 7900319475328460033667 7900319475328460033667 No Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea G.D. Kim 7900319475328460033668 7900319475328460033668 No Department of Microbiology, Pukyong National University, Busan, Korea C.H. Lee 7900319475328460033669 7900319475328460033669 No Department of Neurosurgery, School of Medicine, Pusan National University, Yang-san, Korea H.J. Cho 7900319475328460033670 7900319475328460033670 No Department of Health & Medical Administration, Busan institute of Science and Technology, Busan, Korea J. H. Kwak rlf1007@naver.com 7900319475328460033671 7900319475328460033671 No Department of Radiology, Pusan National University Yang-san Hospital, Yangsan, Korea S. H. Kil kwark9476@naver.com 7900319475328460033672 7900319475328460033672 No Department of Nuclear Medicine, Pusan National University Yang-san Hospital, Yang-san, Korea