|
Analysis of pituitary MRI morphological parameters and changes in 25-hydroxyvitamin D3, free thyroxine, and sex hormone levels in female children with central precocious puberty
|
Z. Zhang   , Y. Wei , Y. Zhang , J. Wen , Y. Lin |
| Department of Radiology, Hainan Women & Children's Medical Center, Haikou, China , Linyi88431@163.com |
|
|
Abstract: (890 Views) |
Background: This study aims to investigate the pituitary MRI morphological parameters and alterations in 25-hydroxyvitamin D3 [25-(OH) D3], free thyroxine (FT4), and sex hormone levels in female children with central precocious puberty (CPP) and assess their clinical relevance. Materials and Methods: From February 2022 to February 2023, 46 female children with CPP and 46 healthy controls were included. Pituitary MRI morphological parameters, 25-(OH) D3, FT4, and sex hormone levels were compared. Diagnostic values of each parameter were assessed. Results: Patients with CPP exhibited higher pituitary height and altered morphology compared to controls, with a higher proportion in grades 4 and 5 (P < 0.05). Coronal and sagittal dimensions were increased, while coronal width was decreased in the study group (P < 0.05). Levels of E2, LH, FSH, and FT4 were elevated, while 25-(OH) D3 was reduced in CPP patients (P < 0.05). Pituitary height, coronal height, and hormone levels showed high diagnostic value for CPP, with AUC values ranging from 0.811 to 0.886. Combined diagnosis using these indicators improved AUC to 0.909. Conclusion: In female children with CPP, significant differences exist in pituitary MRI morphological parameters, sex hormones, 25-(OH) D3 and FT4 levels, providing valuable diagnostic insights for CPP. |
|
| Keywords: Central precocious puberty, pituitary MRI, 25-Hydroxyvitamin D3, Free phyroxine, sex hormones, dagnostic imaging. |
|
|
Full-Text [PDF 647 kb]
(284 Downloads)
|
|
Type of Study: Original Research |
Subject:
Radiation Biology
|
|
|
|
|
|
|
| References |
1. Shi L, Jiang Z and Zhang L (2022) Childhood obesity and central precocious puberty. Frontiers in Endocrinology, 13: 1056871. [ DOI:10.3389/fendo.2022.1056871] [ PMID] [ ] 2. Moise-Silverman J and Silverman LA (2022) A review of the genetics and epigenetics of central precocious puberty. Frontiers in Endocrinology, 13: 1029137. [ DOI:10.3389/fendo.2022.1029137] [ PMID] [ ] 3. Maione L, Bouvattier C and Kaiser UB (2021) Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach. Clinical Endocrinology, 95(4): 542-555. [ DOI:10.1111/cen.14475] [ PMID] [ ] 4. Ceraudo M, Criminelli RD, Di Iorgi N, Cama A, Piatelli G and Consales A (2022) Pediatric pituitary adenoma with mixed FSH and TSH immunostaining and FSH hypersecretion in a 6-year-old girl with precocious puberty: case report and multidisciplinary management. International Journal of Neuroscience, 132(4): 362-369. [ DOI:10.1080/00207454.2020.1815734] [ PMID] 5. Soriano-Guillen L and Argente J (2019) Central precocious puberty, functional and tumor-related. Best Practice & Research Clinical Endocrinology & Metabolism, 33(3): 101262. [ DOI:10.1016/j.beem.2019.01.003] [ PMID] 6. Brito VN, Canton A and Seraphim CE, et al. (2023) The Congenital and Acquired Mechanisms Implicated in the Etiology of Central Precocious Puberty. Endocrine Reviews, 44(2): 193-221. [ DOI:10.1210/endrev/bnac020] [ PMID] [ ] 7. Calcaterra V, Rossi V and Massini G, et al. (2022) Precocious puberty and microbiota: The role of the sex hormone-gut microbiome axis. Frontiers in Endocrinology, 13: 1000919. [ DOI:10.3389/fendo.2022.1000919] [ PMID] [ ] 8. Zevin EL and Eugster EA (2023) Central precocious puberty: a review of diagnosis, treatment, and outcomes. Lancet Child & Adolescent Health, 7(12): 886-896. [ DOI:10.1016/S2352-4642(23)00237-7] 9. Shi Y, Ma Z, Yang X, Ying Y, Luo X and Hou L (2022) Gonadotropin-releasing hormone analogue and recombinant human growth hormone treatment for idiopathic central precocious puberty in girls. Frontiers in Endocrinology, 13: 1085385. [ DOI:10.3389/fendo.2022.1085385] [ PMID] [ ] 10. Lee HS (2023) Central precocious puberty: is routine brain MRI screening necessary for girls? Commentary on "Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?". Annals of Pediatric Endocrinology & Metabolism, 28(3): 155-156. [ DOI:10.6065/apem.2322096edi07] [ PMID] [ ] 11. Yeh SN, Ting WH and Huang CY, et al. (2021) Diagnostic evaluation of central precocious puberty in girls. Pediatrics and Neonatology, 62(2): 187-194. [ DOI:10.1016/j.pedneo.2020.12.001] [ PMID] 12. Calcaterra V, De Filippo G and Albertini R, et al. (2021) Effectiveness of basal LH in monitoring central precocious puberty treatment in girls. Journal of Pediatric Endocrinology & Metabolism, 34(1): 45-50. [ DOI:10.1515/jpem-2020-0386] [ PMID] 13. Phadte A, Sarathi V and Budyal S, et al. (2023) Gonadotropin-Dependent Precocious Puberty: Single-Center Experience from Western India. Indian Pediatrics, 60(6): 463-466. [ DOI:10.1007/s13312-023-2909-y] 14. Vuralli D, Gonc EN, Alikasifoglu A, Kandemir N and Ozon ZA (2021) Central nervous system imaging in girls with central precocious puberty: when is necessary? Archives of Endocrinology Metabolism, 64(5): 591-596. [ DOI:10.20945/2359-3997000000259] [ PMID] [ ] 15. Canton A and Latronico AC (2021) Brain MRI in Girls with Central Precocious Puberty: A Time for New Approaches. Journal of Clinical Endocrinology & Metabolism, 106(7): e2806-e2808. [ DOI:10.1210/clinem/dgab293] [ PMID] 16. Yang XD, Shi JX and Liao WC, et al. (2022) Intervention of Compound Xueshuantong Capsule on the incidence of heart failure in patients with acute myocardial infarction after PCI based on the combination of disease and syndrome: A multi-center, randomized, double-blind, controlled trial. Medicine, 101(50): e32311. [ DOI:10.1097/MD.0000000000032311] [ PMID] [ ] 17. Helvacioglu D, Demircioglu TS and Guran T, et al. (2021) Cranial MRI Abnormalities and Long-term Follow-up of the Lesions in 770 Girls with Central Precocious Puberty. Journal of Clinical Endocrinology & Metabolism, 106(7): e2557-e2566. [ DOI:10.1210/clinem/dgab190] [ PMID] 18. Yu W, Lu Y and Chen T, et al. (2023) Frequency-dependent alterations in regional homogeneity associated with puberty hormones in girls with central precocious puberty: A resting-state fMRI study. Journal of Affective Disorders, 332: 176-184. [ DOI:10.1016/j.jad.2023.03.051] [ PMID] 19. Chen T, Lu Y and Wang Y, et al. (2019) Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty. Neural Plasticity, 2019: 1465632. [ DOI:10.1155/2019/1465632] [ PMID] [ ] 20. Zou P, Zhang L and Zhang R, et al. (2023) Development and Validation of a Combined MRI Radiomics, Imaging and Clinical Parameter-Based Machine Learning Model for Identifying Idiopathic Central Precocious Puberty in Girls. Journal of Magnetic Resonance Imaging, 58(6): 1977-1987. [ DOI:10.1002/jmri.28709] [ PMID] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Zhang Z, Wei Y, Zhang Y, Wen J, Lin Y. Analysis of pituitary MRI morphological parameters and changes in 25-hydroxyvitamin D3, free thyroxine, and sex hormone levels in female children with central precocious puberty. Int J Radiat Res 2024; 22 (4) URL: http://ijrr.com/article-1-5744-en.html
|
