Department of General Surgery, the Second Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China , songail@lzu.edu.cn
Abstract: (1189 Views)
Background:Breast cancer is a common cancer that affects women. The Luminal A subtype of breast cancer is defined by low Ki67 expression (<14%), Her-2 negative, and positive ER and PR. Luminal A exhibits a favorable prognosis compared to other breast cancer types. Materials and Methods: Gene expression profiling was employed in this investigation to discover genes linked to clinical efficacy and recurrence in Luminal A breast cancer tissue samples. The study's overarching goal was to discover new therapeutic targets by deciphering the molecular mechanisms behind Luminal A breast cancer. Results: Our analysis revealed specific genes linked to Luminal A breast cancer, and their expression levels were correlated with clinical outcomes. High expression of certain genes was associated with improved clinical efficacy and a reduced recurrence rate. Conclusion: The study provides valuable insights into the molecular mechanisms of Luminal A breast cancer, offering potential targets for personalized therapeutic approaches.
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Ma J, Gan T, Song A. Gene expression in luminal A breast cancer and its correlation with chemoradiotherapy outcome and recurrence. Int J Radiat Res 2024; 22 (2) :251-256 URL: http://ijrr.com/article-1-5361-en.html