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:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 515-519 Back to browse issues page
Combined sonodynamic therapy and X-ray radiation with methylene blue and gold nanoparticles coated with apigenin: Impact on MCF7 cell viability
A. Neshastehriz , Z. Hormozi-Moghaddam , S.M. Amini , S.M. Taheri , Z. Abedi Kichi
Department of Radiation Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , Hormozimoghadam.z@iums.ac.ir
Abstract:   (612 Views)
Background: This study investigates the efficacy of sonodynamic and low-dose radiation with methylene blue and gold nanoparticles coated with apigenin sonosensitizer on breast cancer cells. Method and Materials: HR-TEM, UV-visible, zeta-potential, FTIR, and DLS were used to confirm the synthesized gold nanoparticles coated with apigenin. The concentration of gold nanoparticles coated with apigenin and methylene blue was calculated, and then ultrasound and 2 Gy x-rays were used to irradiate them. Results: The results showed that sonodynamic therapy in combination with radiation at a concentration of 8 µg/ml nanoparticles and 0.4 µmol methylene blue had a significant effect on cell death (0.26± 0.02). Conclusion: This study highlights the potential of sonodynamic therapy as a non-ionizing and non-invasive treatment, as well as the possibility of eliminating the side effects of cancer treatment by using green nanoparticles rather than chemical sensitizers.
Keywords: Sonodynamic therapy, radiation, gold nanoparticles, Apigenin, methylene blue.
Full-Text [PDF 681 kb]   (185 Downloads)    
Type of Study: Short Report | Subject: Radiation Biology
References
1. 1. Feng X, Wu C, Yang W, et al. (2022) Mechanism-Based Sonodynamic-Chemo Combinations against Triple-Negative Breast Cancer. Int J Molecular Sciences, 23(14): 7981. [DOI:10.3390/ijms23147981]
2. Zhang Q, Bao C, Cai X, et al. (2018) Sonodynamic therapy-assisted immunotherapy: A novel modality for cancer treatment. Cancer Sci, 109(5): 1330- 1345. [DOI:10.1111/cas.13578]
3. Moghaddam ZH, Mokhtari-Dizaji M, Movahedin M, Ravari ME (2017) Estimation of the distribution of low-intensity ultrasound mechanical index as a parameter affecting the proliferation of spermatogonia stem cells in vitro. Ultrason Sonochem, 37: 571- 581. [DOI:10.1016/j.ultsonch.2017.02.013]
4. Bistas E and Sanghavi D (2023) Methylene Blue. StatPearls. Treasure Island (FL): StatPearls Publishing.
5. Yan P, Liu L-H, Wang P (2020) Sonodynamic therapy (SDT) for cancer treatment: Advanced sensitizers by ultrasound activation to injury tumor. ACS Applied Bio Materials, 3(6): 3456- 3475. [DOI:10.1021/acsabm.0c00156]
6. Choi J, Kim G, Cho SB, Im H-J (2020) Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme. J Nanobiotechnology, 18(1): 122. [DOI:10.1186/s12951-020-00684-5]
7. Rajendran I, Dhandapani H, Anantanarayanan R, Rajaram R (2015) Apigenin mediated gold nanoparticle synthesis and their anti-cancer effect on human epidermoid carcinoma (A431) cells. RSC Advances, 5(63): 51055- 51066. [DOI:10.1039/C5RA04303D]
8. Jiang J, Mao Q, Li H, Lou J-l (2017) Apigenin stabilized gold nanoparticles increased radiation therapy efficiency in lung cancer cells. Int J Clin Exp Med, 10(9): 13298- 13305.
9. Amini SM, Mohammadi E, Askarian-Amiri S, et al. (2021) Investigating the in-vitro photothermal effect of green synthesized apigenin-coated gold nanoparticle on colorectal carcinoma. IET Nanobiotechnol, 15(3): 329- 337. [DOI:10.1049/nbt2.12016]
10. Mariappan DG, Sundaraganesan G, Shanmugam M (2012) The spectroscopic properties of anticancer drug Apigenin investigated by using DFT calculations, FT-IR, FT-Raman and NMR analysis. Spectrochimica acta Part A, Molecular and Biomolecular Spectroscopy, 95: 86-99. [DOI:10.1016/j.saa.2012.04.089]
11. Haiss W, Thanh NT, Aveyard J, Fernig DG (2007) Determination of size and concentration of gold nanoparticles from UV-vis spectra. Anal Chem, 79(11): 4215- 4221. [DOI:10.1021/ac0702084]
12. Ahmadi F, McLoughlin IV, Chauhan S, ter-Haar G (2012) Bio-effects and safety of low-intensity, low-frequency ultrasonic exposure. Prog Biophys Mol Biol, 108(3): 119- 138. [DOI:10.1016/j.pbiomolbio.2012.01.004]
13. Katiyar A, Osborn J, DasBanerjee M, et al. (2020) Inhibition of Human Breast Cancer Cell Proliferation by Low-Intensity Ultrasound Stimulation. J Ultrasound Med, 39(10): 2043- 2052. [DOI:10.1002/jum.15312]
14. Barati AH and Mokhtari-Dizaji M (2010) Ultrasound dose fractionation in sonodynamic therapy. Ultrasound Med Biol, 36(6): 880-887. [DOI:10.1016/j.ultrasmedbio.2010.03.010]
15. Suzuki N, Okada K, Chida S, et al. (2007) Antitumor effect of acridine orange under ultrasonic irradiation in-vitro. Anticancer Research, 27(6b): 4179- 4184.
16. Komori C, Okada K, Kawamura K, et al. (2009) The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro. Anticancer research. 29(6): 2411- 2415.
17. Xiang J, Xia X, Jiang Y, et al. (2011) Apoptosis of ovarian cancer cells induced by methylene blue-mediated sonodynamic action. Ultrasonics, 51(3): 390- 395. [DOI:10.1016/j.ultras.2010.11.005]
18. Kong T, Zeng J, Wang X, et al. (2008) Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. (Weinheim an der Bergstrasse, Germany); Small, 4(9): 1537- 1543. [DOI:10.1002/smll.200700794]
19. Liu CJ, Wang CH, Chen ST, et al. (2010) Enhancement of cell radiation sensitivity by pegylated gold nanoparticles. Physics in Medicine and Biology, 55(4):931- 945. [DOI:10.1088/0031-9155/55/4/002]
20. Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J (2020) Flavonoids as anticancer agents. Nutrients, 12(2): 457. [DOI:10.3390/nu12020457]
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Neshastehriz A, Hormozi-Moghaddam Z, Amini S, Taheri S, Abedi Kichi Z. Combined sonodynamic therapy and X-ray radiation with methylene blue and gold nanoparticles coated with apigenin: Impact on MCF7 cell viability. Int J Radiat Res 2024; 22 (2) :515-519
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Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
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