[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
IJRR Information::
For Authors::
For Reviewers::
Subscription::
News & Events::
Web Mail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
ISSN
Hard Copy 2322-3243
Online 2345-4229
..
Online Submission
Now you can send your articles to IJRR office using the article submission system.
..

AWT IMAGE

AWT IMAGE

:: Volume 22, Issue 4 (10-2024) ::
Int J Radiat Res 2024, 22(4): 823-829 Back to browse issues page
Dosimetry calculations of gastric cancer treatment during pencil beam scanning proton therapy
S. Sadrzadeh , M. Tajik
School of Physics, Damghan University, P.O. Box 36716-41167, Damghan, Iran , tajik@du.ac.ir
Abstract:   (444 Views)
Background: In this study, Monte Carlo simulations were performed to estimate the dose of proton therapy to involved and uninvolved organs in gastric cancer. Materials and Methods: The dose received by involved and uninvolved organs during gastric treatment was simulated during pencil beam scanning proton therapy using the MIRD-UF phantom and the MCNPX code. In this modeling, the appropriate energy range for tumor treatment in the gastric tissue of an adult male MIRD-UF phantom with monoenergetic proton beams was calculated. The dose secondary charged particles, neutrons and photons in the tumor and vital organs were evaluated. Results: The results showed that, depending on the size of the tumor, the appropriate and optimal range of proton energy to cover the tumor is 67 - 81.5 MeV. The distribution of energy deposition, total primary dose, and the ratio of neutron equivalent dose to absorbed therapeutic dose (H/D) were calculated for the tumor and 12 vital organs. The ratio between the total received dose of the healthy gastric tissue and the delivered dose of the tumor was about 0.0046. The average photon equivalent dose was about 0.9% of the neutrons. The highest H/D ratios for normal stomach, spleen, pancreas, and left kidney tissue were 0.167 mSv/Gy, 0.0362 mSv/Gy, 0.0231 mSv/Gy and 0.0143 mSv/Gy, respectively. Conclusion: In the study, a small gastric tumor in an adult male phantom was irradiated with high-energy protons. Proton therapy delivered the highest possible dose to the tumor, while the healthy organs received a low dose.
Keywords: Proton therapy, Gastric Cancer, Neutrons, Pencil Beam.
Full-Text [PDF 964 kb]   (118 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. Schardt D, Elsässer T, Schulz-Ertner D (2010) Heavy-ion tumor therapy Physical and radiobiological benefits. Reviews of Modern Physics, 82(1): 383. [DOI:10.1103/RevModPhys.82.383]
2. Paganetti H (2018) Proton therapy physics: CRC press; 2018 Nov 19. [DOI:10.1201/b22053]
3. Mohan R, Grosshans D (2017) Proton therapy-present and future. Advanced Drug Delivery Reviews, 109: 26-44. [DOI:10.1016/j.addr.2016.11.006] [PMID] []
4. Ahmadi Ganjeh Z, Eslami-Kalantari M, Mowlavi AA (2019) Dosimetry calculations of involved and noninvolved organs in proton therapy of liver cancer: a simulation study. Nuclear Science and Techniques, 30(12): 1-7. [DOI:10.1007/s41365-019-0698-8]
5. Maroufkhani F, Abtahi SMM, Kakavand T (2021) Assessment of secondary particles in breast proton therapy by Monte Carlo simulation code using MCNPX. Int J Radiat Res, 19(1): 23-29. [DOI:10.29252/ijrr.19.1.23]
6. Jia SB, Mowlavi AA, Hadizadeh MH, Ebrahimi Loushab M (2014) Impact of range straggling and multiple scattering on proton therapy of brain, using a slab head phantom. International Journal of Radiation Research, 12(2): 161-167.
7. Ouar M, Amine Dib AS, Belkaid MN, Belbachir AH (2022) Monte Carlo simulation of a new proton therapy technique using bio-nanoparticles and high energy proton beams. International Journal of Radiation Research, 20(3): 615-619.
8. Gillin MT, Sahoo N, Bues M, Ciangaru G, Sawakuchi G, Poenisch F, et al. (2010) Commissioning of the discrete spot scanning proton beam delivery system at the University of Texas MD Anderson Cancer Center, Proton Therapy Center, Houston. Medical Physics, 37(1): 154-163. [DOI:10.1118/1.3259742] [PMID] []
9. Jafari NA, Tajik, M (2024) Reducing secondary particle dose in proton therapy for gastric tumors: a material optimization study. Journal of Theoretical and Applied Physics, 18(5): 1-11.
10. Dionisi F, Avery S, Lukens JN, Ding X, Kralik J, Kirk M, et al. (2014) Proton therapy in adjuvant treatment of gastric cancer: planning comparison with advanced x-ray therapy and feasibility report. Acta Oncol, 53(10): 1312-1320. [DOI:10.3109/0284186X.2014.912351] [PMID]
11. Ling TC, Kang JI, Slater JD, Yang GY (2012) Proton therapy for gastrointestinal cancers. Translational Cancer Research, 1(3):150-158.
12. Mondlane G, Gubanski M, Lind PA, Ureba A, Siegbahn A (2017) Comparison of gastric-cancer radiotherapy performed with volumetric modulated arc therapy or single-field uniform-dose proton therapy. Acta Oncologica, 56(6): 832-838. [DOI:10.1080/0284186X.2017.1297536] [PMID]
13. Mondlane G, Ureba ANA, Gubanski M, Lind PA, Siegbahn A (2018) Estimation of Risk of Normal-tissue Toxicity Following Gastric Cancer Radiotherapy with Photon- or Scanned Proton-beams. Anticancer Research, 38(5): 2619. [DOI:10.21873/anticanres.12503]
14. Koyama S, Kawanishi N, Fukutomi H, Osuga T, Iijima T, Tsujii H, Kitagawa T(1990) Advanced carcinoma of the stomach treated with definitive proton therapy. Am J Gastroenterol, 85(4): 443-447.
15. Shibuya S, Takase Y, Aoyagi H, Orii K, Sharma N, Tsujii H, et al. (1991) Definitive proton beam radiation therapy for inoperable gastric cancer: a report of two cases. Radiat Med, 9(1): 35-40.
16. Kobeissi JM, Simone CB, Hilal L, Wu AJ, Lin H, Crane CH, Hajj C (2022) Proton Therapy in the Management of Luminal Gastrointestinal Cancers: Esophagus, Stomach, and Anorectum. Cancers, 14(12): 2877. [DOI:10.3390/cancers14122877] [PMID] []
17. Chuong M, Badiyan SN, Yam M, Li Z, Langen K, Regine W, et al. (2018) Pencil beam scanning versus passively scattered proton therapy for unresectable pancreatic cancer. Journal of Gastrointestinal Oncology, Vol 9, No 4 (August 2018). [DOI:10.21037/jgo.2018.03.14] [PMID] []
18. Weber DC, Ares C, Lomax AJ, Kurtz JM (2006) Radiation therapy planning with photons and protons for early and advanced breast cancer: an overview. Radiation Oncology, 1(1): 1-11. [DOI:10.1186/1748-717X-1-22] [PMID] []
19. Agosteo S, Birattari C, Caravaggio M, Silari M, Tosi G (1998) Secondary neutron and photon dose in proton therapy. Radiotherapy and Oncology, 48(3): 293-305. [DOI:10.1016/S0167-8140(98)00049-8]
20. Schneider U, Agosteo S, Pedroni E, Besserer J (2002) Secondary neutron dose during proton therapy using spot scanning. International Journal of Radiation Oncology Biology Physics, 53(1): 244-251. [DOI:10.1016/S0360-3016(01)02826-7]
21. Asadi A, Hosseini SA, Akhavanallaf A, Vosoughi N, Zaidi H (2022) Comparative assessment of passive scattering and active scanning proton therapy techniques using Monte Carlo simulations. Journal of Instrumentation, 17(09): P09008. [DOI:10.1088/1748-0221/17/09/P09008]
22. Dent B, Griffin SM (2014) Gastric tumours. Surgery (Oxford), 32(11): 608-613. [DOI:10.1016/j.mpsur.2014.09.002]
23. Im WJ, Kim MG, Ha TK, Kwon SJ (2012) Tumor size as a prognostic factor in gastric cancer patient. Journal of Gastric Cancer, 12(3): 164-172. [DOI:10.5230/jgc.2012.12.3.164] [PMID] []
24. Maughan RL, Chuba P, Porter AT, Ben‐Josef E, Lucas DR, Bjarngard BE (1999) Mass energy‐absorption coefficients and mass collision stopping powers for electrons in tumors of various histologies. Medical Physics, 26(3): 472-477. [DOI:10.1118/1.598544]
25. Hendricks JS, McKinney GW, Fensin ML, James MR, Johns RC, Durkee JW, et al. (2008) MCNPX 2.6. 0 Extensions. Los Alamos National Laboratory, 2008 Apr, 11: 73.
26. Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS, Suit HD (2002) Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat OncolBiol Phys, 53(2): 407-421. [DOI:10.1016/S0360-3016(02)02754-2]
27. American Nuclear Society (1977) Working Group ANS. American national standard neutron and gamma-ray flux-to-dose-rate factors: American Nuclear Society.
28. Zheng Y, Newhauser W, Fontenot J, Taddei P, Mohan R (2007) Monte Carlo study of neutron dose equivalent during passive scattering proton therapy. Phys Med Biol, 52(15): 4481-4496. [DOI:10.1088/0031-9155/52/15/008] [PMID]
29. OriginPro 2024 (Learning Edition) ed (2024) Nort Hampton, MA, USA.: OriginLab Corporation; 2024.
30. Rezaee L (2018) Design of spread-out Bragg peaks in hadron therapy with oxygen ions. Reports of Practical Oncology and Radiotherapy, 23(5): 433-441. [DOI:10.1016/j.rpor.2018.08.004] [PMID] []
31. Badiyan SN, Hallemeier CL, Lin SH, Hall MD, Chuong MD (2018) Proton beam therapy for gastrointestinal cancers: past, present, and future. J Gastrointest Oncol, 9(5): 962-971. [DOI:10.21037/jgo.2017.11.07] [PMID] []
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sadrzadeh S, Tajik M. Dosimetry calculations of gastric cancer treatment during pencil beam scanning proton therapy. Int J Radiat Res 2024; 22 (4) :823-829
URL: http://ijrr.com/article-1-5721-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 4 (10-2024) Back to browse issues page
International Journal of Radiation Research
Persian site map - English site map - Created in 0.06 seconds with 50 queries by YEKTAWEB 4682