en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: In this study, human absorbed dose of a newly introduced bone imaging agent, 68Ga-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (68Ga-BPAMD), was estimated based on the rats data. Materials and Methods: ⁶⁸Ga was obtained from the ⁶⁸Ge/⁶⁸Ga generator and it&#39;s radionuclidic and radiochemical purities were investigated. ⁶⁸Ga-BPAMD complex was prepared at optimal conditions and the radiochemical purity was studied using instant thin layer chromatography (ITLC) method. The final preparation was injected to the normal rats and the biodistribution of the complex was followed up to 120 min post injection. The accumulated activity for animal organs was calculated. Finally, the human absorbed dose of the complexes was estimated by RADAR method. Results: ⁶⁸Ga-BPAMD complex was prepared in high radiochemical purity (>99%, ITLC) at optimal conditions. The biodistribution of the complex demonstrated that the main remained radioactivity would considerably accumulate into the bones. The results showed the highest amounts of absorbed dose on the bone surface (0.253 mGy/MBq) and in the bone marrow (0.250 mGy/MBq), while the other organs would receive an insignificant absorbed dose after injection of the⁶⁸Ga-BPAMD complex. Conclusion: The comparison of dosimetric results for ⁶⁸Ga-BPAMD with other complexes shows this complex is a safer agent for bone scanning. This property as well as other characteristics such as the high resolution images of the positron emission tomography (PET) scanning and the availability of ⁶⁸Ga in the form of ⁶⁸Ge/⁶⁸Ga generator, make this complex as a suitable agent for PET bone imaging.</div> Absorbed dose, Bone metastases, BPAMD, Ga-68, Positron emission tomography. 473 480 http://ijrr.com/browse.php?a_code=A-10-1-746&slc_lang=en&sid=1 A. Rabiei 7900319475328460012273 7900319475328460012273 No Department of Energy Engineering and Physics, Amir Kabir University of Technology, Tehran, Iran M. Shamsaei 7900319475328460012274 7900319475328460012274 No Department of Energy Engineering and Physics, Amir Kabir University of Technology, Tehran, Iran H. Yousefnia hyousefnia@aeoi.org.ir 7900319475328460012275 7900319475328460012275 Yes Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran A.R. Jalilian 7900319475328460012276 7900319475328460012276 No Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran