en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The aim of this retrospective study was to evaluate the therapeutic outcomes and organ preservation in patients with squamous cell carcinoma of the buccal mucosa treated with radiotherapy and retrograde superselective intra-arterial chemotherapy. Materials and Methods: Between April 2006 and March 2016, 28 patients (3 with stage II; 8 with stage III; and 17 with stage IV) with squamous cell carcinoma of the buccal mucosa were treated with definitive intra-arterial chemoradiotherapy. The median follow-up for all patients was 39months (range, 4-123months&nbsp;). Catheterization of the tumor feeding arteries from the superficial temporal and/or occipital arteries was performed. Treatment consisted of radiotherapy (total 50-70 Gy) and daily concurrent superselective&nbsp;&nbsp;&nbsp; intra-arterial chemotherapy (docetaxel, 50-70 mg/m2, cisplatin, total 125-175 mg/m2) for 5-7 weeks. Results: After intra-arterial chemoradiotherapy, primary site complete response was achieved in 25 (89.3%) of 28 cases. Three-year local control and overall survival rates were 82.1% and 85.4%, respectively. Grade 3 or 4 toxicities included mucositis in 96.4%, and dermatitis in 28.6% of patients. Grade 3 toxicities included dysphagia in 35.7%, neutropenia in 28.6%, anemia in 10.7%, and fever in 7.1% of patients. Conclusion: Retrograde superselective intra-arterial chemoradiotherapy for squamous cell carcinoma of the buccal mucosa provided good local control and overall survival.</div> Carcinoma of the buccal mucosa, Chemoradiotherapy, Intra-arterial infusion, Oral cancer, Organ preservation. 283 291 http://ijrr.com/browse.php?a_code=A-10-1-783&slc_lang=en&sid=1 J.T. Koizumi 7900319475328460013050 7900319475328460013050 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan S. Minamiyama 7900319475328460013051 7900319475328460013051 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan Y. Hayashi 7900319475328460013052 7900319475328460013052 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan K. Osawa 7900319475328460013053 7900319475328460013053 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan N. Ohashi 7900319475328460013054 7900319475328460013054 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan T. Ohya 7900319475328460013055 7900319475328460013055 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan M. Iida 7900319475328460013056 7900319475328460013056 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan T. Iwai 7900319475328460013057 7900319475328460013057 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan S. Oguri 7900319475328460013058 7900319475328460013058 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan M. Hirota 7900319475328460013059 7900319475328460013059 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan M. Kioi 7900319475328460013060 7900319475328460013060 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan K. Mitsudo mitsudo@yokohama-cu.ac.jp 7900319475328460013061 7900319475328460013061 Yes Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-Ku, Yokohama, Kanagawa 236-0004 Japan