en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To evaluate the predictive value at the hepatobiliary phase (HBP) magnetic resonance imaging (MRI) after gadobenate dimeglumine (Gd-BOPTA) injection for histologic grades of hepatocellular carcinoma (HCC). Materials and Methods: HCC patients who underwent Gd-BOPTA-enhanced MRI were analyzed and divided into four histologic grades of differentiation based on Edmonson-Steiner grade. Besides, HCC tumor differentiations grade I, II and III, IVwere defined as well-differentiated (WD), moderately-differentiated (MD), poorly-differentiated (PD), respectively. The clinical, pathological and imaging features of patients were assessed. Receiver operating characteristic (ROC) curve was to evaluate the significance between WD/MD HCC and PD HCC using the apparent diffusion coefficient (ADC), relative intensity ratio (RIR) of T1WI and T2WI (T1RIR, T2RIR), contrast-enhancement ratio in arterial phase (CERA) and contrast-noise-ratio (CNR) in HBP (CNR_hbp). Results: A total of 102 HCC patients were analyzed (grade I, &nbsp;n=19; grade II, n=30; grade III, n=30; grade IV, n=23). There was no statistical difference regarding to the pathological and clinical features among four grades. There were significant differences in CERA, CNR_hbp, T1RIR, T2RIR and ADC values among the four HCC grades (all P<0.05). Based on ROC curve, comparison of the five quantitative MRI parameters indicated ADC (sensitivity 84.8%, specificity 82.6%, AUC 0.862) and CNR_hbp value (sensitivity 78.5%, specificity 91.3%, AUC 0.916) could significantly distinguish the HCC histological grade. Conclusions: The ADC and/or CNR_hbp value in HBP-MRI after GD-BOPTA injection might be as the significant quantitative parameters to distinguish HCC histological grade.</div> Hepatocellular carcinoma, gadobenate dimeglumine, magnetic resonance imaging, apparent diffusion coefficient, contrast noise ratio. 791 799 http://ijrr.com/browse.php?a_code=A-10-1-868&slc_lang=en&sid=1 G. Li 7900319475328460021393 7900319475328460021393 No Department of Radiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250014, P.R. China L. Hu 7900319475328460021394 7900319475328460021394 No Department of Radiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, P.R. China Y. Wang 7900319475328460021395 7900319475328460021395 No Department of Radiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, P.R. China X. Wang 7900319475328460021396 7900319475328460021396 No Department of Radiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, P.R. China Q. Zeng 7900319475328460021397 7900319475328460021397 No Department of Radiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, P.R. China Z. Xu 7900319475328460021398 7900319475328460021398 No Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, P.R. China X. Yang 7900319475328460021399 7900319475328460021399 No Department of Pathology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, P.R. China T. Li 7900319475328460021400 7900319475328460021400 No Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, P.R. China H. Sun qysunhongjun@163.com 7900319475328460021401 7900319475328460021401 Yes Department of Radiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250014, P.R. China H. Shi hansenschie@163.com 7900319475328460021402 7900319475328460021402 No Department of Radiology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250014, P.R. China