International Journal of Radiation Research

en Efficacy of Hematoporphyrin mediated photo-sonodynamic therapy on mice breast cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: A combination of photodynamic and sonodynamic therapy (PSDT) may be a non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound, laser radiation, and a sensitizer agent. The goal of this research was to evaluate the effect of PSDT with Hematoporphyrin-encapsulated Mesoporous silica nanoparticles (HP-MSNs) as a sensitizer in the management of mice breast adenocarcinoma. Materials and Methods: One hundred and fifty-six female mice (tumor grafted) were separated into 26 groups; including sham, laser (650 nm), 4 groups of laser + HP or MSN-HP (2.5 and 5 mg/kg), 4 groups of laser + ultrasound (1and 3 MHz; 1, 2 W/cm2), 16 groups of PSDT + HP or HP-MSN. The tumor growth factors were used to assess the procedure findings. Results: The results indicate that PSDT with an injection of HP or HP-MSN is effective in delaying tumor growth (P<0.05). Overall comparison of data showed a non-significant difference between PSDT with HP-MSN groups. The time of T2 and T5 in the groups of PSDT with HP-MSN were increased in comparison with sham and that of PSDT with HP groups (P<0.05). The tumor growth inhibition ratio increased in all PSDT groups. This increase was transient and declined over 30 days of treatment. PSDT + HP-MSN had Grade I, while other groups had Grade III malignancy in the histological study. Conclusion: The research gave profound findings involving the employ of PSDT with HP-MSN as a photo/sonosensitizer for treating breast adenocarcinoma implanted in mice.</div>     Photodynamic therapy, sonodynamic therapy, laser, ultrasound, breast cancer. 555 561 http://ijrr.com/browse.php?a_code=A-10-1-945&slc_lang=en&sid=1 S. Moshfegh 7900319475328460021911 7900319475328460021911 No Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran M. Jadidi Jadidim@semums.ac.ir 7900319475328460021912 7900319475328460021912 Yes Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran H. Hasanzadeh 7900319475328460021913 7900319475328460021913 No Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran R. Nasr 7900319475328460021914 7900319475328460021914 No Biotechnology Research Center, Semnan University of Medical Sciences, Semnan, Iran M. Mirmohammadkhani 7900319475328460021915 7900319475328460021915 No Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran