en Radiation Biology Radiation Biology مقاله مروری Review article <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Radiation-induced brain injury (RIBI) is a common complication in patients with head and neck tumors. RIBI usually occurs six months to three years after therapy and is often accompanied by cognitive dysfunction, epilepsy, and other neurological dysfunctions. In severe cases, RIBI can cause a wide range of cerebral edema and herniation. A systematic search was conducted through PubMed/Medline, EMBASE, and Cochrane library databases and articles with the keywords radiation-induced brain injury, pathogenesis and protective agents were collected. The commonly known pathogenesis of RIBI includes vascular injury, </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">immune-inflammatory response, glial cell damage, and neuronal damage. Therapeutic agents, hyperbaric oxygen, surgery, and stem cells transplantation are the most common treatment </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">for RIBI. Tamoxifen, curcumin, and quercetin can prevent glial cell activation, proliferation, and oxidative stress caused by irradiation. Over recent years, the RIBI remission rate has gradually increased; however, there are still no effective prevention and treatment methods. This review summarized recent progress in the treatment for RIBI, as well as the pathogenesis of RIBI, including vascular injury, glial cell injury, immune-inflammatory response, and neuronal damage.</span></span></span></span></span></span></span></span></span></span></div> Radiation-induced brain injury (RIBI), conventional medicine, pathogenesis, hyperbaric oxygen (HBO), protective agents. 727 736 http://ijrr.com/browse.php?a_code=A-10-1-971&slc_lang=en&sid=1 Y. Zhang 7900319475328460022521 7900319475328460022521 No Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China G. Ou 7900319475328460022522 7900319475328460022522 No Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Q. Li 7900319475328460022523 7900319475328460022523 No Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China S. Ma mashan76@sina.com 7900319475328460022524 7900319475328460022524 Yes School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China L. Du 7900319475328460022525 7900319475328460022525 No Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China