en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Although radioiodine</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">-131 </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">(</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">¹³¹</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">I) has been widely used for the treatment of Graves&#39; disease (GD), radiation is a potential risk factor for mutagenic abnormalities. This retrospective clinical study mainly aimed to investigate the influence of maternal exposure to 131I used for the treatment of GD prior to pregnancy on chromosomal aberration and intellectual development of offspring in China. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> total,</span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">69 children whose mothers received </span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">¹³¹</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">I </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">for the</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> treatment </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">of GD</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> during childbearing age were included. Data on the obstetric history, medical records, and the birth characteristics of the children were obtained. The thyroid function, thyroid ultrasound, chromosomal structure, and somatic and intellectual development of the children were measured. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In all</span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">66 women, the range of the administered </span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">¹³¹</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">I was within 228.2 &plusmn; 70.3 MBq. The </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">height</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> and </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">weight</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> of all children were within the normal ranges, and one child was confirmed as having subclinical hypothyroidism. Two children were diagnosed with benign thyroid nodules, one child was diagnosed with thyroid cysts, and one child was confirmed as having several anechoic areas in both lobes of the thyroid gland. Chromosomal aberration was observed in one child. None of the children showed any abnormalities in somatic and/or intellectual development. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This is the first study to confirm that </span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">¹³¹</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">I used for the treatment of GD prior to pregnancy does not significantly increase the risk of chromosomal aberration or impair </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">the</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> intellectual development of offspring.</span></span></span></span></span></span></span></span></span></div> <span style="font-size:10pt"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black">&nbsp;</span></span></span></span><br> &nbsp; Graves' disease, 131-I treatment, chromosomal structure, intellectual development. 785 791 http://ijrr.com/browse.php?a_code=A-10-1-979&slc_lang=en&sid=1 J. Zeng 7900319475328460022570 7900319475328460022570 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China J. Wang 7900319475328460022571 7900319475328460022571 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China Q. Guo 7900319475328460022572 7900319475328460022572 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China Y. Hou 7900319475328460022573 7900319475328460022573 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China Q. Lei 7900319475328460022574 7900319475328460022574 No Department of Paediatrics, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China B. Yao 7900319475328460022575 7900319475328460022575 No Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China J. Lan 7900319475328460022576 7900319475328460022576 No Department of Neurology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China D. Zheng 7900319475328460022577 7900319475328460022577 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China Q. Feng 7900319475328460022578 7900319475328460022578 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China Z. Li 7900319475328460022579 7900319475328460022579 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China F. Chen 7900319475328460022580 7900319475328460022580 No Department of Nuclear Medicine, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China J. Xing 7900319475328460022581 7900319475328460022581 No Department of Nuclear Medicine, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China Y. Fang 7900319475328460022582 7900319475328460022582 No Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China