en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To investigate the clinical efficacy of hyperthermic intraperitoneal chemotherapy in combination with the malignant ascites in gastric cancer following the Intensive preoperative radiotherapy for radical surgery of tumor. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">We selected a total of 112 gastric cancer patients who had been operated on for radical surgery of tumor in this hospital as subjects that were randomized into the control group and the observation group, with 56 patients in each group. Patients in the control group took the abdominal aspiration in combination with the intravenous chemotherapy, while those in the observation group underwent the hyperthermic intraperitoneal chemotherapy. After treatment, we compared the effectiveness rate, levels of tumor markers, incidence rates of adverse reactions, and </span></span></span>&nbsp;<span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#00000a"><span style="language:en-US">Karnofsky (KPS) scores between the two groups.</span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In the observation group and the control group, the effectiveness rates of patients were 71.43% and 44.64%, showing the statistical significance of the difference (</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="font-style:italic"><span style="language:en-US">P < </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">0.05); after treatment, the levels of CEA, CA125, and CA199, tumor markers, were decreased compared to before treatment (</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="font-style:italic"><span style="language:en-US">P < </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">0.05). The incidence rates of adverse reactions were 75.00% and 82.14%, showing no statistical significance of difference (</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="font-style:italic"><span style="language:en-US">P ></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> 0.05). Following the treatment, the KPS scores were improved in two groups compared to before treatment (</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="font-style:italic"><span style="language:en-US">P < </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">0.05). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">For gastric cancer patients with malignant ascites, hyperthermic intraperitoneal chemotherapy excels in the clinical efficacy by decreasing the level of tumor markers, to improve the life quality of patients, but with no increase in the incidence rate of adverse reactions.</span></span></span></span></span></span></span></span></span></div> Pelvis, Environmental radioactivity, internal hazard, gamma emitters, NaI (Tl), soil, Najaf schools. 865 869 http://ijrr.com/browse.php?a_code=A-10-1-990&slc_lang=en&sid=1 Z. Wang 7900319475328460022727 7900319475328460022727 No Department of Surgical Oncology, The First People’s Hospital of Lanzhou, Lanzhou, Gansu730050, China P. Wang 7900319475328460022728 7900319475328460022728 No Department of Internal Medicine, Nanjing Gaochun People's Hospital, Jiangsu Province, Nanjing, Jiangsu 211300, China L. Lv 7900319475328460022729 7900319475328460022729 No Department of Internal Medicine, Nanjing Gaochun People's Hospital, Jiangsu Province, Nanjing, Jiangsu 211300, China Y. Liu 7900319475328460022730 7900319475328460022730 No Department of Hand and Foot Surgery, Subei People's Hospital of Jiangsu province, Yangzhou, Jiangsu 225000, China C.J. Sun prof.lililuolililuo253@gmail.com 7900319475328460022731 7900319475328460022731 No Department of Oncology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225000, China