International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61882/ijrr
en
jalali
1401
10
1
gregorian
2023
1
1
21
1
online
1
fulltext
en
Dosimetric comparison of the heart substructures with IMRT and VMAT techniques in left breast radiotherapy: The effect of deep inspiratory breath-hold
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:inter-word"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="tr" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:tr">This study aimed to compare the doses received by the four chambers and vascular structures of the heart during adjuvant radiotherapy (RT) after left breast-conserving surgery (BCS) using intensity-modulated RT (IMRT) and volumetric</span></span></span><span lang="tr" style="font-size:9.0pt"><span style="language:tr">-modulated</span></span><span lang="tr" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:tr"> arc therapy (VMAT) techniques.</span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Material and</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Simulation images were taken of 14 patients who underwent left BCS with both free-breathing (FB) and deep inspiration breath-hold (DIBH) techniques. Left breast RT was planned with both IMRT and VMAT. Planned target volumes 50 and 60, homogeneity index, conformity index, and monitor unit values, as well as radiation doses received by organs at risk, were compared. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In IMRT compared to VMAT, in the </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">heart (D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>10</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>2</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US"> ) and heart substructures (left ventricle [V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>5</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">] , right ventricle [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], right atrium [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], left atrium [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>5</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], right coronary artery [RCA; D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], left artery coronary main [LACM; D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], and left circumflex artery [LCxA; D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">]), significant dose reductions were observed. When FB and DIBH results were compared, in the DIBH technique, the heart (D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>25</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>10</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>2</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">) and heart substructures (left ventricle [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>23</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>5</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], right ventricle [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], right atrium [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], left atrium [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], left anterior descending artery [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, V</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>20</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], RCA [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], LACM [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">], and LCxA [D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>mean</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, D</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US"><sub>max</sub></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">]), doses were significantly decreased. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">In RT of patients with left BCS, significant dose reductions occurred in the lung, heart, and almost all substructures of the heart using DIBH compared to FB.</span></span></span></span></span></span></span></span></span></div>
Left breast cancer, breast-conserving surgery, IMRT, VMAT, DIBH, heart substructure radiation doses.
23
30
http://ijrr.com/browse.php?a_code=A-10-1-1000&slc_lang=en&sid=1
A.
Arslan
alaettin.arslan@gmail.com
7900319475328460023030
7900319475328460023030
Yes
Kayseri City Hospital, Clinic of Radiation Oncology, Doctor, Kayseri City Hospital, Kayseri, Turkey
E.
Aktaş
7900319475328460023031
7900319475328460023031
No
Kayseri City Hospital, Clinic of Radiology, Doctor, Kayseri City Hospital, Kayseri, Turkey
S.K.
Eren
7900319475328460023032
7900319475328460023032
No
Kayseri City Hospital, Clinic of General Surgery, Doctor, Kayseri City Hospital, Kayseri, Turkey
I.
Dengiz
7900319475328460023033
7900319475328460023033
No
Kayseri City Hospital, Clinic of Radiation Oncology, Health Physicist, Kayseri City Hospital, Kayseri, Turkey
S.A.
Arslan
7900319475328460023034
7900319475328460023034
No
Ankara Memorial Hospital, Clinic of Radiation Oncology, Doctor, Ankara Memorial Hospital, Ankara, Turkey
Y.
Güney
7900319475328460023035
7900319475328460023035
No
Ankara Memorial Hospital, Clinic of Radiation Oncology, Doctor, Ankara Memorial Hospital, Ankara, Turkey