en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:inter-word"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Due to the disinfection and antibiotic resistance of microorganisms, there is a growing interest in ultraviolet-C (UV-C). UV-C has numerous advantages, and the applications of this method for fluids, surfaces, and air are rapidly expanding. However, nothing is known about how UV-C affects living bodies. This study&#39;s objective is to assess the results of 10 sessions of 10- to 20-minute UV-C exposure on healthy guinea pigs. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">After five days of UV-C treatment, blood and visceral organ samples were collected and analyzed. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Moreover, the hematological and biochemical analyses of the blood samples revealed no significant changes. According to histopathological examination, UV-C treatment did not cause any damage to internal organs. Except for the intestine, caspase-3 immunohistochemistry revealed no increase in apoptotic activity. In the UV-C-treated groups, only minor apoptotic activity was observed in intestinal goblet cells. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study found that repeated UV-C exposure for ten sessions lasting 10-20 minutes did not result in any pathological findings in the guinea pig model. This result suggested that UV-C could be used for barn and pen disinfection when animals are present as well as udder disinfection prior to milking.</span></span></span></span></span></span></span></span></div> UV-C, treatment, Guinea pig, pathology. 45 51 http://ijrr.com/browse.php?a_code=A-10-1-1003&slc_lang=en&sid=1 O. Ozmen ozlemozmen@mehmetakif.edu.tr 7900319475328460023043 7900319475328460023043 Yes Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey V. Ipek 7900319475328460023044 7900319475328460023044 No Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey S.A. Tasan 7900319475328460023045 7900319475328460023045 No Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey L.E.O. Ayozger 7900319475328460023046 7900319475328460023046 No Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey M. Altintas 7900319475328460023047 7900319475328460023047 No Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey