en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">The purpose of this study is to evaluate the accuracy of </span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">¹⁸</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">F-fluorodeoxyglucose (FDG) positron emission tomography/Computed Tomography (PET/CT) in predicting tumor prognosis in patients with Small Cell Lung Cancer (SCLC). </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US"> From July 2015 to March 2019, all 30 SCLC patients who had analyzable PET/CTs and adequate clinical data were evaluated. Medical records were retrospectively reviewed, including age, gender, stage, performance status&nbsp;according&nbsp;to&nbsp;the&nbsp;Eastern Cooperative Oncology Group&nbsp;(ECOG), metabolic parameters on PET and treatment programs. Factors potentially affecting tumor prognosis were examined by models of univariate and multivariate Cox proportional hazards regression. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">The median age of the cohort was 58 years (range: 39-93). A median follow-up period of 12 months was observed. Multivariate Cox proportional hazards regression demonstrated that the overall survival (OS) (p</span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">= 0.03) and progression-free survival (PFS) (p = 0.014)</span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">were related only to the metabolic tumor volume (MTV). The optimal cutoff threshold was 98 mm</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">³</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">, and the receiver operating characteristic (ROC) curve had an area under it of 0.75. In comparison to the high-MTV group, the low-MTV group had statistically substantially prolonged OS (p = 0.004) and PFS (p < 0.001). </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> The MTV of </span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">¹⁸</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">F-FDG PET/CT is a major independent prognostic factor in SCLC patients and has significant implications for OS and PSF.</span></span></span></span></span></span></span></span></span></div> Positron emission, computed tomography, lung cancer patients. 211 215 http://ijrr.com/browse.php?a_code=A-10-1-1030&slc_lang=en&sid=1 X. Chen 7900319475328460023469 7900319475328460023469 No Department of Ultrasound, The First People’s Hospital of Xiaoshan District, 311200, Hangzhou, Zhejiang, P.R. China L. Shen 7900319475328460023470 7900319475328460023470 No Department of Ultrasound, The First People’s Hospital of Xiaoshan District, 311200, Hangzhou, Zhejiang, P.R. China Y. Hong hyp139640@126.com 7900319475328460023471 7900319475328460023471 Yes Department of Anorectal Surgery, The First People’s Hospital of Xiaoshan District, 311200, Hangzhou, Zhejiang, P.R. China