International Journal of Radiation Research

en Stereotactic radiotherapy and cytokines: preliminary analysis in oligometastatic Non-Small-Cell lung cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Cytokines have a recognized role in the physiopathology of cancer disease and could be involved also in the “abscopal effect”. Aim of this work is the preliminary analysis of inflammatory mediators in patients with oligometastatic non-small-cell lung cancer (NSCLC) undergoing stereotactic radiotherapy (SRT). Materials and Methods: This was a feasibility multi-institutional study that prospectively included oligometastatic NSCLC patients undergoing SRT from June 2018 until August 2018 and healthy controls. Blood samples were collected at three different time points (1-5 days before SRT, 1-5 days after SRT and 28-35 days after SRT). A commercially available kit was used for quantitative analysis of 44 inflammation molecules. Nine patients and four healthy controls were enrolled. Results:  Several cytokines (54.5%) resulted undetectable in a significant percentage of the samples and were not further analyzed. Levels of seven inflammatory molecules (bDNF, MIP-1b, PDGF-bb, PIGF-1, RANTES, SDF1-a, and bNGF) showed significant variations after SRT in the NSCLC patients cohort. Conclusion: Significant plasmatic concentration changes after SRT were reported for a relevant proportion of the evaluated molecules. The results of this study will contribute to define a selection of cytokines and chemokines that will be analyzed in a prospective trial with a larger sample of patients.</div> Stereotactic radiotherapy, cytokines, oligometastatic, lung cancer. 247 254 http://ijrr.com/browse.php?a_code=A-10-1-1035&slc_lang=en&sid=1 P. Borghetti 7900319475328460023615 7900319475328460023615 No Department of Radiation Oncology, University and Spedali Civili Hospital of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy A.E. Guerini 7900319475328460023616 7900319475328460023616 No Department of Radiation Oncology, University and Spedali Civili Hospital of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy A. Colosini giorgio.facheris@gmail.com 7900319475328460023617 7900319475328460023617 No Department of Molecular and Translational Medicine, Unit of Biotechnology, University of Brescia, Brescia, Italy G. Facheris 7900319475328460023618 7900319475328460023618 Yes Department of Radiation Oncology, University and Spedali Civili Hospital of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy C. Gandolfo 7900319475328460023619 7900319475328460023619 No Microbiology Unit, Department of Medical Biotechnologies, University of Siena, Le Scotte Hospital, Siena, Italy L. Triggiani 7900319475328460023620 7900319475328460023620 No Department of Radiation Oncology, University and Spedali Civili Hospital of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy A. Bruni 7900319475328460023621 7900319475328460023621 No Radiotherapy Unit, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy E. D’Angelo 7900319475328460023622 7900319475328460023622 No Radiotherapy Unit, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy M. Grazia Cusi 7900319475328460023623 7900319475328460023623 No Microbiology Unit, Department of Medical Biotechnologies, University of Siena, Le Scotte Hospital, Siena, Italy S.M. Magrini 7900319475328460023624 7900319475328460023624 No Department of Radiation Oncology, University and Spedali Civili Hospital of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy R. Bresciani 7900319475328460023625 7900319475328460023625 No Department of Molecular and Translational Medicine, Unit of Biotechnology, University of Brescia, Brescia, Italy V. Nardone 7900319475328460023626 7900319475328460023626 No Department of Precision Oncology, University of Campania “L. Vanvitelli”, Naples, Italy