International Journal of Radiation Research

en Non-invasive radiomics nomogram model for determining the low and high-grade glioma base on MRI images Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Glioma is the most common type of tumor in the nervous system. Glioma grading remains challenging despite advancements in diagnostic and treatment systems. Preoperative classification is essential to determining optimal treatment and prognosis for gliomas. This study aimed to use magnetic resonance imaging (MRI) to develop accurate nomogram models for glioma grading. Materials and Methods: Eighty-three patients who had undergone a glioma biopsy from June 2017 to November 2021 were retrospectively collected. Two multiparametric MRIs were acquired: T2-weighted and T1-weighted gadolinium contrast-enhanced of 83 glioma patients from one medical institution. Using the open-source python package PyRadiomics, 107 radiomics features were identified for each sequence MRI. We analyzed the probabilities of low-grade gliomas (LGG) and high-grade gliomas (HGG) using logistic regression and the least absolute shrinkage and selection operator regression (LASSO). We identified seven features affecting LGG and HGG differentiated using the lasso algorithm. Next, logistic regression analysis was performed to build a classification model, and five features were obtained. Nomograms were created to predict the incidence of HGG and LLG. To evaluate the prediction performance of the models, receiver operating characteristic (ROC) curves were plotted, and the area under the curve (AUC), sensitivity, specificity, and accuracy were calculated. Results: For multivariate logistic regression models, according to the best-selected features based on MRI images and clinical data, five parameters were independent predictors of LGG from HGG (P<0.001). The highest prediction performance in terms of AUC, sensitivity, specificity, and accuracy was 0.97, 89.19%, 91.11%, and 90.24%, respectively. Conclusion: The radiomics nomogram models created from quantitative images and clinical data performed well in differentiating LGG from HGG.</div> Glioma, low-grade glioma (LGG), high-grade glioma (HGG), radiomics, nomogram. 275 280 http://ijrr.com/browse.php?a_code=A-10-1-1039&slc_lang=en&sid=1 S. Bijari 7900319475328460023695 7900319475328460023695 No Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran A. Jahanbakhshi 7900319475328460023696 7900319475328460023696 No Stem Cell and Regenerative Research Center, Iran University of Medical Sciences, Tehran, Iran P. Abdolmaleki parviz@modares.ac.ir 7900319475328460023697 7900319475328460023697 Yes Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran