International Journal of Radiation Research

en Prophylactic irradiation meta-analysis in reducing procedure tract metastasis incidence in malignant pleural mesothelioma Radiation Biology Radiation Biology مقاله مروری Review article <div style="text-align: justify;">Background: Malignant pleural mesothelioma (MPM) diagnoses are primarily based on pleural biopsy. Invasive procedures may result in iatrogenic dissemination of tumor cells along the subcutaneous channels. The purpose of our study was to clarify the effect of prophylactic radiotherapy on the incidence of metastasis in patients afflicted with MPM. Materials and Methods: Relevant studies were searched in PubMed, Cochrane Library, and Embase databases from the establishment of the library to February 2022. The quality of the included studies was evaluated, and the data were statistically analyzed. Results: Seven articles were obtained, and 1030 patients were included in the study, which allowed comparison of the procedure to track metastases (PTMs) incidences between radiotherapy and control groups. The results revealed statistically significant differences in the incidence of PTMs between the two groups (OR=0.48, 95% confidence interval [CI]:0.33, 0.69, p<0.0001). Subgroup analysis further showed that preventive radiotherapy could effectively reduce the incidence of PTMs in MPM patients who underwent large-caliber invasive procedures but could not reduce the incidence of PTMs after small-caliber invasive procedures. Prophylactic radiotherapy in patients with epithelial PTM types could reduce the incidence (OR=0.27, 95% CI:0.11, 0.69, P=0.006). Conclusion: Prophylactic radiotherapy is safe and can effectively prevent the occurrence of iatrogenic PTMs in patients with epithelial MPM who have undergone thoracotomy, thoracoscopy, indwelling chest wall drainage tubes, and other large-caliber operations.</div> Malignant pleural mesothelioma, prophylactic irradiation, procedure tract metastases. 343 348 http://ijrr.com/browse.php?a_code=A-10-1-1050&slc_lang=en&sid=1 H-F Chen 7900319475328460023845 7900319475328460023845 No Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China C-W Xu 7900319475328460023846 7900319475328460023846 No Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, People's Republic of China W-X Wang 7900319475328460023847 7900319475328460023847 No Department of Chemotherapy, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou Zhejiang 310022, People's Republic of China L-C Huang 7900319475328460023848 7900319475328460023848 No Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China P-E Chen 918576941@qq.com 7900319475328460023849 7900319475328460023849 Yes Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China X-F Li 7900319475328460023850 7900319475328460023850 No Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China G. Lan 7900319475328460023851 7900319475328460023851 No Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China Z-Q Zhai 7900319475328460023852 7900319475328460023852 No Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China Y-C Zhu 7900319475328460023853 7900319475328460023853 No Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China K-Q Du 7900319475328460023854 7900319475328460023854 No Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, People's Republic of China M-Y Fang 7900319475328460023855 7900319475328460023855 No Department of Chemotherapy, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou Zhejiang 310022, People's Republic of China