en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">The impact of doses on the left ventricle (LV) and left anterior descending artery (LAD) in relation to major adverse cardiac events is well documented. Studies performed on breast cancer have shown that LV doses are correlated with cardiac toxicity. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Thirty-two patients with left lung cancer who received radiotherapy at our center were evaluated retrospectively. The left ventricle (LV) and left anterior descending artery (LAD) were contoured as organs at risk on CT simulation images. Seven fields were used in intensity-modulated radiation therapy (IMRT) plans, while two partial arcs were used to create volumetric modulated arc therapy (VMAT) plans. Conventional plans were compared with LV and LAD sparing plans dosimetrically. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">When comparing conventional plans to sparing plans, no statistically significant differences were found in target volume parameters and values related to critical structures (p>0.05). However, when evaluating the heart (Dmean and V25) and its substructures (LADmean, V15, V30, and LV V5, V10, V15, V30, V40), the plan with LV and LAD sparing demonstrated significantly better outcomes (p<0.05). </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Therefore, it is essential to contour the substructures of the heart as organs at risk, particularly including LAD and LV in the optimization algorithm during radiotherapy planning for central lung tumors located near the heart.</span></span></span></span></span></span></span></span></span></span></div> Left Lung Cancer, intensity-modulated radiotherapy, volumetric modulated arc therapy, left ventricle and left anterior descending artery, heart-protecting radiotherapy. 627 632 http://ijrr.com/browse.php?a_code=A-10-1-1091&slc_lang=en&sid=1 I.H. Suyusal suyusalih@yahoo.com 7900319475328460024840 7900319475328460024840 Yes Kocaeli University Radiation Oncology Department, Kocaeli, Turkey A.O. Konuk 7900319475328460024841 7900319475328460024841 No Kocaeli University Radiation Oncology Department, Kocaeli, Turkey U. Diremsizoglu 7900319475328460024842 7900319475328460024842 No Kocaeli University Radiation Oncology Department, Kocaeli, Turkey