en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Background: Ultraviolet radiation is the main cause of photoaging, which can induce oxidative stress and cellular senescence in the skin. It has been demonstrated that platelet-rich plasma (PRP) can significantly improve skin photoaging. However, the mechanism by which PRP improves photoaging remains unclear. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">In this study, UVA-induced SD rats were used as a skin photoaging model and administered with PRP treatment, aiming to elucidate the potential mechanism of its protection against photoaging. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">They showed that PRP injection on the back of rats improved skin photoaging, oxidative stress, and inflammation, and inhibited skin cell apoptosis. In addition, RPR activated autophagy to inhibit NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome signaling pathway-related proteins. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Our experimental results suggest that PRP plays an anti-UVA photoaging role by inhibiting autophagy and NLRP3 signaling pathways. Our study is the first to suggest that PRP anti-skin photoaging is associated with autophagy and NLRP3, providing a potential therapeutic approach for skin photoaging.</span></span></span></span></span></span></span></span></span></span></div> Platelet-rich plasma, skin aging, autophagy, NLR proteins. 745 750 http://ijrr.com/browse.php?a_code=A-10-1-1108&slc_lang=en&sid=1 Y. Zeng dong9894@126.com 7900319475328460025061 7900319475328460025061 Yes Department of dermatology, Meizhou people's Hospital, Meizhou, 514000, China D. Zhang 7900319475328460025062 7900319475328460025062 No Department of dermatology, Dongshan Hospital, Meizhou, 514000, China H. Lai 7900319475328460025063 7900319475328460025063 No Department of dermatology, Meizhou people's Hospital, Meizhou, 514000, China S. Liu 7900319475328460025064 7900319475328460025064 No Department of dermatology, Meizhou people's Hospital, Meizhou, 514000, China