en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Brain tumors like intracranial metastases, meningioma, gliomas, etc are the most prevalent brain tumors. Magnetic Resonance Spectroscopy (MRS) helps in the differentiation of high grade, low grade brain tumors, brain neoplasms, etc. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">This study was conducted in the Radiology Department of one of the major tertiary health care centers in South Kerala. Patients suspected of brain tumors were subjected to both MRS and histopathological examinations after the surgery. A total of 69 patients were included. Histopathological findings were evaluated and grouped as benign, atypical, and anaplastic tumors and correlated with MRS findings. Statistical analysis was done by SPSS version 16. Friedman test was used for comparison. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">In this study, MRS images of 69 brain tumor lesions were studied and compared for metabolic ratios and pathogenesis. MRS spectrum gives different peaks of specific metabolites of brain tumors like lipid, alanine, lactate, glycine, glutamate /glutamine, myoinositol, etc. Histopathological results also show different pathological findings. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusions:&nbsp; </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Magnetic Resonance Spectroscopy has a wide range of sensitivity to and is evaluate the different metabolites of brain lesions. The quantification of tissue metabolites can potentially identify the pathological change, at the biochemical level which creates further therapeutic interventions.</span></span></span></span></span></span></span></span></span></span></div> brain tumors, magnetic resonance spectroscopy, metabolites 769 777 http://ijrr.com/browse.php?a_code=A-10-1-1116&slc_lang=en&sid=1 H. Smitha smithavinod2000@yahoo.co.in 7900319475328460025134 7900319475328460025134 Yes Department of Physics, Noorul Islam Centre of Higher Education, Kumarakovil, Kanyakumari & Department of Physiology, Sree Gokulam Medical College & Research Foundation, Venjaramoodu.P.O. Trivandrum, India V.N. Meena Devi 7900319475328460025135 7900319475328460025135 No Department of Physics, Noorul Islam Centre of Higher Education, Kumarakovil, Kanyakumari, India K.S. Sreekanth 7900319475328460025136 7900319475328460025136 No epartment of Biochemistry, Sree Gokulam Medical College & Research Foundation, enjaramoodu.P.O.Trivandrum, India J. Vinoo 7900319475328460025137 7900319475328460025137 No Department of Radio Diagnosis, Sree Gokulam Medical College & Research Foundation, Venjaramoodu.P.O.Trivandrum, India