en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To explore the application of intravoxel incoherent motion (IVIM) parameters based on mono- and bi-exponential models for diagnosing breast cancer (BC). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">43 patients underwent breast magnetic resonance (MR) scanned before operation and the images were transferred to AW Volume Share 5 post-processing workstation. The mono-exponential and bi-exponential model was used to measure the slow diffusion coefficient (DC) (D), fast DC (D*) and fraction of perfusion (f). And the association between different parameter values and BC grading was analyzed via Spearman&rsquo;s rank correlation coefficient. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The D mono value of 13 patients with benign breast diseases was higher than that of 30 patients with BC (4.04 &plusmn; 0.23 vs 2.59 &plusmn; 0.64</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:SimSun"><span style="language:en-US">，</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">p<0.05) while there was no statistical significance on the value of D* mono, f mono, D bi, D* bi and f bi. Additionally, the parameter differences of D mono, D* mono, D bi and D* bi had statistical significance between the different BC grades. And the grades of BC had a negative correlation with D mono and D bi while were positively related to D* mono and D* bi. It was most closely related to D* bi than D bi. D mono value in ER-positive were higher than that in ER-negative group (3.09&plusmn;0.37 vs 1.03&plusmn;0.09, p=.0095). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">IVIM could be used to diagnose BC, predict histological grading and ER expression and provide valuable imaging for the clinical treatment and prognosis of BC patients.</span></span></span></span></span></span></span></span></span></div> Breast cancer, magnetic resonance imaging, intravoxel incoherent motion, histological grading, diffusion-weighted imaging. 827 832 http://ijrr.com/browse.php?a_code=A-10-1-1123&slc_lang=en&sid=1 S. Chen 7900319475328460025250 7900319475328460025250 No Department of breast surgery, The Second Hospital of Shandong University, Jinan, Shandong, 250033, China D. Wang 7900319475328460025251 7900319475328460025251 No Department of Medical Imagin, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250033, China P. Kong 7900319475328460025252 7900319475328460025252 No Department of breast surgery, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China H. Gu 7900319475328460025253 7900319475328460025253 No Department of breast surgery, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China Z. Yu yuzhigang@sdu.edu.cn 7900319475328460025254 7900319475328460025254 Yes Department of breast surgery, The Second Hospital of Shandong University, Jinan, Shandong, 250033, China