en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To assess the diagnostic value of ultrasound (US) combined with mammography in breast cancer with different clinical and pathological features. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Totally 340 female patients with breast cancer were enrolled in this study. All patients underwent color ultrasound and mammography examination and the diagnostic efficiency in breast cancer with different clinical and pathological features was assessed. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The diagnostic sensitivity of ultrasound in breast cancer with different Body Mass Index (BMI), initial symptom, histological grade, and hormone receptor (HR) status was similar. The diagnostic sensitivity of mammography in breast cancer with different histological grade, HR status and Ki-67 positive rate was similar. However, the diagnostic sensitivity of ultrasound and mammography was higher in age &ge;50 years, human epidermal growth factor receptor 2 (HER2) positive patients. The diagnostic sensitivity of ultrasound in Ki-67 positive rate >20 was higher than that in Ki-67 positive rate &le;20. The diagnostic sensitivity of mammography was higher in BMI >30 and in the initial symptom with calcification. Moreover, in different molecular subtypes, the diagnostic sensitivity of ultrasound and mammography in HR+HER2+ was the highest, followed by HR-HER2+, HR-HER2- and HR+HER2-. The diagnostic efficiency of ultrasound combined with mammography in different age, BMI, initial symptom, histological grade and HR status was similar. In addition, the diagnostic efficiency of ultrasound combined with mammography was higher than single ultrasound and mammography. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Ultrasound combined with mammography showed high diagnostic efficiency in breast cancer with different clinical and pathological features was high, and is worthy for clinical promotion.</span></span></span></span></span></span></span></span></span></span></div> Breast cancer, ultrasound, mammography, cancer diagnosis. 49 54 http://ijrr.com/browse.php?a_code=A-10-1-1137&slc_lang=en&sid=1 Y. Xu 7900319475328460025855 7900319475328460025855 No Department of Breast Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China J. Qian 7900319475328460025856 7900319475328460025856 No Department of Breast Surgery, The Women's and Children's Hospital of Linping District Hangzhou, Hangzhou, Zhejiang 311199, China F. Wang 7900319475328460025857 7900319475328460025857 No Department of Breast Surgery, The Women's and Children's Hospital of Linping District Hangzhou, Hangzhou, Zhejiang 311199, China Y. Chen cyd963136@163.com 7900319475328460025858 7900319475328460025858 Yes Department of Breast Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China