en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Chamomile is a supplementary food all over the world. The chamomile inhibitive effect on neurodegenerative disorders in </span></span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:el">&gamma;-</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">irradiated mice was investigated. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Twenty-four mice were divided into 4 groups; control, chamomile-treated, </span></span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:el">&gamma;-</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">irradiated (8 Gy), and chamomile-treated and irradiated. Brain total thiols, lipid peroxidation (LP), nitric oxide (NO), reduced- and oxidized-glutathiones (GSH & GSSG), protein carbonyl (PC), antioxidant enzymatic activities and acetylcholinesterase (AChEA) were measured. The brain histopathology sections were observed. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">A significant increase of levels of total thiols, LP, NO, GSSG, PC and AChEA activity and a decrease of the antioxidant enzymatic activities in the 8 Gy gamma-irradiated group compared to the controls. In chamomile-treated all estimated indices were considerably ameliorated in respect to control standards. Also, the chamomile intake has diminished the histopathological cerebrum alterations such as severe congestion, perivascular oedema, several apoptotic neurons and spongy degenerative changes. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Chamomile may protect the brain from oxidative injury induced by </span></span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:el">&gamma;-</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">rays through its ability to inhibit LP, replenish the GSH level and antioxidant enzymes activity.</span></span></span></span></span></span></span></span></span></span></div> Chamomile, neurodegenerative disorders, γ-rays, mice. 155 161 http://ijrr.com/browse.php?a_code=A-10-1-1151&slc_lang=en&sid=1 S.S. Tawfik 7900319475328460026003 7900319475328460026003 No Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), P. O. Box 29, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt A.A. Elkady elkadyah13@gmail.com 7900319475328460026004 7900319475328460026004 Yes Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), P. O. Box 29, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt R.M. Ebrahim 7900319475328460026005 7900319475328460026005 No Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), P. O. Box 29, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt W.A. El khouly 7900319475328460026006 7900319475328460026006 No Radiation Protection Department, Nuclear and Radiation Safety Research Center (NRSRC), P. O. Box: 7551, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt A.A. Ali 7900319475328460026007 7900319475328460026007 No Pathology Department, Faculty of Veterinary Medicine, Zagazig University