en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Diagnosing knee osteoarthritis (KOA) often relies on limited routine methods. This study investigates the efficacy of T2 mapping and Apparent Diffusion Coefficient (ADC) values in MRI for enhanced assessment of cartilage damage in KOA, focusing on their correlation with pain severity. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A total of 52 KOA patients (74 knee joints) and 50 healthy individuals (100 knee joints) were assessed from May 2022 to June 2023. Both groups underwent MRI with Diffusion Weighted Imaging (DWI) sequence and T2 mapping to analyze ADC and T2 mapping values across femoral condyle, tibial plateau, and patellar joint surfaces, and their correlation with pain levels. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The KOA group showed significantly higher ADC and T2 mapping values in all examined areas compared to the control group (P<0.05). These values were also higher in advanced stages of cartilage degeneration and correlated positively with increased pain scores (P<0.05). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">MRI utilizing DWI and T2 mapping provides a quantitative reflection of knee joint cartilage degeneration in KOA. These methods show a positive correlation with pain severity, suggesting their potential for more accurate KOA diagnostics and assessment.</span></span></span></span></span></span></span></span></span></div> Knee osteoarthritis (KOA), magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), T2 mapping, cartilage degeneration. 271 275 http://ijrr.com/browse.php?a_code=A-10-1-1169&slc_lang=en&sid=1 C.Z. Huang 7900319475328460027057 7900319475328460027057 No Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China C.K. Lin 724897505@qq.com 7900319475328460027058 7900319475328460027058 Yes Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China Q.M. Fu 7900319475328460027059 7900319475328460027059 No Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China J.H. Huang 7900319475328460027060 7900319475328460027060 No Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China N.L. Jia 7900319475328460027061 7900319475328460027061 No Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China Y. Chen cheny86a@163.com 7900319475328460027062 7900319475328460027062 No Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China