International Journal of Radiation Research

en Application of Doppler ultrasound and pregnancy-associated plasma protein A in fetal growth restriction prediction Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To investigate the role of pregnant-associatedplasma protein A (PAPP-A) and uterine artery Doppler ultrasound in predicting fetal growth restriction (FGR). Materials and Methods: In total, 120 pregnant women diagnosed with FGR in Shijiazhuang Obstetrics and Gynecology Hospital from January 2021 to December 2023 were selected as the FGR group, and 120 normal pregnant women were selected as the control group during the identical time frame. Maternal serum pregnancy-related protein A combined with uterine artery Doppler ultrasonography was performed during the period from the 11th, to the 13th+6 weeks of pregnancy. The course of pregnancy was observed in both groups of pregnant women. Results: The FGR group exhibited significantly reduced rates of vaginal delivery and fetal survival compared to the control group, while experiencing higher rates of preterm delivery and cesarean section, with statistical significance (P<0.001). The pulsatility index of the uterine artery (UtA-PI) and the resistance index of the uterine artery and the FGR group exhibited a higher proportion of early blood diastolic incisors compared to the normal group, with statistical significance noted at a level of P<0.001. The concentration of PAPP-A was lower than that of normal group (P<0.001). The sensitivity of combining UtA-PI and PAPP-A to predict FGR was 81.6%, and the sensitivity of combining UtA-PI and PAPP-A is 82.9%, which is 1.3% higher, but there was no statistically significant distinction between the two approaches (P>0.05). Conclusion: The implementation the combination between PAPP-A and Doppler ultrasound is an effective method to predict FGR.</div> Doppler ultrasound, PAPP-A, fetal growth restrictionFGR. 297 302 http://ijrr.com/browse.php?a_code=A-10-1-1173&slc_lang=en&sid=1 F. Li 13472192605@163.com 7900319475328460026858 7900319475328460026858 Yes The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China F. Liu 7900319475328460026859 7900319475328460026859 No The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China W. Song 7900319475328460026860 7900319475328460026860 No The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China H. Li 7900319475328460026861 7900319475328460026861 No The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China