International Journal of Radiation Research

en Efficacy of radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombosis Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The To investigate the feasibility, efficacy, and toxicity of three-dimensional conformal radiotherapy (3D-CRT) for treatment of patients with advanced hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombosis (PVTT) and/or inferior vena cava tumor thrombosis (IVCTT). Materials and Methods: 53 HCC patients with PVTT/IVCTT undergoing 3D-CRT during the period from September 2008 to January 2014 were analyzed. The Kaplan-Meier method was used to analyze between-group differences in patient baseline information. Univariate and multivariate cox regression analyses were used to identify factors affecting survival in patients with HCC. Results: Computed tomography (CT) scan or MRI (Magnetic Resonance Imaging) of the upper abdomen one month post-radiotherapy showed an overall response rate (CR + PR) of 56.6% (30/53). Univariate analysis revealed that treatment regimen (P = 0.008), alpha fetoprotein (AFP) level (P = 0.012), response to radiotherapy, metastasis to celiac lymph nodes and site of tumor thrombosis were strongly associated with the prognosis of HCC patients with PVTT (P = 0.000). The median survival time was 9 months (95% CI: 7.43-10.57 months) in 23 (43.4%) PVTT patients, and 24 months (95% CI: 20.04-27.96 months) in 30 (56.6%) IVCTT patients. Multivariate Cox regression analysis revealed that metastasis to celiac lymph nodes (P = 0.004) and response to radiotherapy (P = 0.001) were independent factors affecting patients’ survival. Conclusion: 3D-CRT has high efficacy for treating HCC patients with PVTT, and metastasis to celiac lymph nodes and response to radiotherapy are primary factors affecting HCC patients’ survival.</div> Hepatocellular carcinoma, Portal vein tumor thrombosis, Inferior vena cava, Three-dimensional conformal radiotherapy, Clinical efficacy. 379 385 http://ijrr.com/browse.php?a_code=A-10-1-1185&slc_lang=en&sid=1 Q. Tian 7900319475328460027769 7900319475328460027769 No Department of Radiation Oncology, Shangdong Provincial Third Hospital, Jinan Shandong 250031, P.R. China. L. Li 7900319475328460027770 7900319475328460027770 No Department of Radiation Oncology, Shangdong Provincial Third Hospital, Jinan Shandong 250031, P.R. China. F. Zhang 7900319475328460027771 7900319475328460027771 No Department of Gastroenterology, Shandong Second Provincial General Hospital, Jinan Shandong, 250000, P.R. China X. Wu wywx7606@163.com 7900319475328460027772 7900319475328460027772 Yes Department of Radiation Oncology, Shangdong Provincial Third Hospital, Jinan Shandong 250031, P.R. China.