en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In this work, we investigated the effect of adding 0.3% w/w of the non-toxic substance agarose to the dosimeter formulation of genipin radiochromic gel, which was named LCA-GENA (Low Concentration Agarose-GENipin and Agarose) gel dosimeter.&nbsp; </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A compact linear accelerator with a beam quality of 6 MV and a dose rate of&nbsp; 200 cGy/min irradiated the produced gel dosimeters in a dose range of 0-10 Gy. A UV-Visible spectrophotometer was used to read out the irradiated gel dosimeters. Calibration curves for both absorbance peak and area-under-spectrum responses were investigated. Furthermore, the physical and radiological characteristics of the new formulation were investigated. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The results showed that the dose sensitivity of the LCA-GENA gel dosimeter under the irradiated conditions is (8.4&nbsp;&plusmn;&nbsp;0.15)&nbsp;&times;&nbsp;10</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">^-3</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">&nbsp;cm</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">^-1</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">&nbsp;Gy</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">^-1</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">. Results showed adding the abovementioned percentage of agarose will increase the melting point of the genipin gel dosimeter from 24&deg;C to 28&deg;C. Also, an investigation of the radiological properties of the novel formulation revealed that this radiochromic gel is water equivalent. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">From the obtained results, it is verified that adding 0.3% w/w agarose to the genipin gel dosimeter leads to an increase in the melting point of the original genipin gel dosimeter, easier fabrication, and lower price than that of higher agarose concentrations. The mentioned features make this gel suitable for dosimetry applications in clinical and radiotherapy environments.</span></span></span></span></span></span></span></span></span></div> Radiochromic gel dosimeter, dose sensitivity, GENA, radiological properties. 427 433 http://ijrr.com/browse.php?a_code=A-10-1-1191&slc_lang=en&sid=1 S.M.M. Abtahi sm.abtahi@sci.ikiu.ac.ir 7900319475328460027795 7900319475328460027795 Yes Physics Department, Imam Khomeini International University, Qazvin, Iran F. Bahrami 7900319475328460027796 7900319475328460027796 No Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran D. Sardari 7900319475328460027797 7900319475328460027797 No Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran