International Journal of Radiation Research

en Treatment modalities and prognostic factors in patients with Masaoka-Koga stage III thymoma: a single center study Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Clinical stage and the ability to achieve comprehensive treatment were the prognostic features of thymoma. In the present study, we aimed to analyze the efficacy of different types of therapy in patients with Masaoka-Koga stage III thymoma. Materials and Methods: From 2001 to 2018, patients newly diagnosed with thymoma was retrospectively analyzed. The c2test was used to evaluate patient characteristics, the Kaplan-Meier method was used to calculate overall survival (OS), log-rank method was applied to examine the difference between groups, and Cox regression was used to analysis the potential prognostic factors of OS. Results: The median follow-up time was 50 months (range: 3-221 months), and median OS was 51 (range: 3-221) months. The radical surgery group had a significantly better OS than the palliative surgery group. The 5- year, 10-year OS were 88.2%, 74.4% in the radical surgery group, whereas the 5- year, 10-year OS were 51.8% and 32.4% in the palliative group. The 5-year OS in surgery followed by adjuvant radiotherapy group was higher than that of surgery alone group (82.8% vs 55.8%, P=0.033); similarly, the 10-year OS of the two groups were 64.2% and, 50.2%, respectively (P＜0.05). Multivariate analysis revealed that age < 50 years (HR [hazard ratio]: 0.264), radical resection (HR:0.134, P=0.000), and surgery combined with radiotherapy (HR:2.778, P=0.009) were independently associated with better OS. Conclusion: In Masaoka-Koga stage III thymoma, patients treated with radical surgery was capable of achieving better OS than patients treated with palliative surgery. Moreover, radical surgery was an independent factor of prognosis.</div> Thymoma, surgery, radiotherapy, overall survival, prognosis. 435 441 http://ijrr.com/browse.php?a_code=A-10-1-1192&slc_lang=en&sid=1 Z. Song 7900319475328460027798 7900319475328460027798 No Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China M. Zhuang 7900319475328460027799 7900319475328460027799 No Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China Z. Jin 7900319475328460027800 7900319475328460027800 No Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China Y. Gao 7900319475328460027801 7900319475328460027801 No Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China B. Bian bbx5720620@sina.cn 7900319475328460027802 7900319475328460027802 Yes Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China