International Journal of Radiation Research

en Effect of Different Radiotherapy Techniques on the Left Anterior Descending Coronary Artery Dose in Left-Sided Lung Cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: This study aims to compare the radiation doses delivered to the heart and left anterior descending artery (LAD) when using Volumetric Modulated Arc Therapy (VMAT) and Intensity Modulated Radiotherapy (IMRT) for the treatment of left-sided lung cancer. Materials and Methods: We selected 29 stage III lung cancer patients for replanning. Step and shoot IMRT(S&S-IMRT), dynamic IMRT(D-IMRT), full arc VMAT (FA-VMAT) and two partial arc VMAT (2PA-VMAT) techniques were used in plan recreation for each patient. Difference between heart and LAD doses were investigated using dose volume histogram. Results: FA-VMAT technique resulted in lower LAD mean (Dmean) (1712.43 cGy, p < 0.001), LAD maximum (Dmax), LAD 2% (D2%) (3527.33 cGy, p = 0.003), LAD 0.1cc (D0.1cc) (3473.12 cGy, p=0.006) doses and percentage of LAD that received 15Gy (V15) (43.69%, p < 0.001). No statistical difference was observed between the two partial arc VMAT and full arc VMAT techniques in LAD doses. Comparing cardiac V10, V15, and heart mean doses (MHD), the 2PA-VMAT technique showed better organ protection than FA-VMAT, S&S IMRT, and D-IMRT.2PA-VMAT and FA-VMAT showed similar results in cardiac V5, V20, V25, V30, V40 and V45 values. When the median heart volume (567 cc) was used as a threshold, those with heart volume smaller than 567cc had statistically significant differences in LAD and heart doses in favor of 2PA-VMAT (p < 0.005). Conclusion: VMAT technique protects LAD and heart better than IMRT technique in left-sided lung cancer patients.</div> Radiotherapy, Lung cancer, Left Anterior Coronary Artery, Volumetric Modulated Arc Therapy, IMRT, Dose Comparison. 617 623 http://ijrr.com/browse.php?a_code=A-10-1-1217&slc_lang=en&sid=1 A. Konuk aykut.oguz.konuk@hotmail.com 7900319475328460027936 7900319475328460027936 Yes Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey I.H. Suyusal 7900319475328460027937 7900319475328460027937 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey A.U. Karabey 7900319475328460027938 7900319475328460027938 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey G. Ozkan 7900319475328460027939 7900319475328460027939 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey B. Tirpanci 7900319475328460027940 7900319475328460027940 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey U. Diremsizoglu 7900319475328460027941 7900319475328460027941 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey O. Ari 7900319475328460027942 7900319475328460027942 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey A. Ucuncu kefeli 7900319475328460027943 7900319475328460027943 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey E.B. Sarper 7900319475328460027944 7900319475328460027944 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey M.G. Aksu 7900319475328460027945 7900319475328460027945 No Department of Radiation Oncology, School of Medicine, Kocaeli University, Izmit 41001, Turkey