International Journal of Radiation Research

en Effects of different doses of computed tomography radiation on the oxidation markers, antioxidant enzymes, and lipid profiles of male albino rats Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The study investigates the effects of four different doses of computed tomography (CT) x-ray radiation on the oxidation markers, endogenous antioxidant enzymes, and lipid profiles of male Wistar albino rats. Materials and methods: Thirty healthy male Wistar albino rats weighing 180-200g were assigned into five groups of 6 rats each. Rats in groups A, B, C, and D underwent non-contrast helical total body irradiation and received varying doses of CT radiation, while group E received sham irradiation and served as a control. Glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) activities, serum levels of malondialdehyde (MDA), oxidized glutathione (GSSG), nitric oxide (NO), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were investigated using standard methods. Results: At 72 hours’ post-irradiation, the mean serum activities of GPx, SOD, and CAT in the irradiated groups decreased significantly, while the serum levels of MDA, GSSG, TC, and LDL increased significantly compared to the control. Conclusion: The four different doses of CT radiation in the current study caused a significant decline in the endogenous antioxidant enzymes (GPx, SOD, and CAT) and, in contrast, induced a significant serum elevation of MDA and GSSG in the irradiated rats. The LDC and TC mean serum levels were also significantly elevated in the irradiated groups.</div> Rats, antioxidants, catalase, glutathione disulfide, nitric oxide, whole-body CT radiation. 631 637 http://ijrr.com/browse.php?a_code=A-10-1-1219&slc_lang=en&sid=1 K.C. Ogbanya 7900319475328460027950 7900319475328460027950 No Department of Veterinary Surgery and Radiology, University of Nigeria, Nsukka, Nigeria E.K. Mgbe emeka.mgbe@unn.edu.ng 7900319475328460027951 7900319475328460027951 Yes Department of Radiation Medicine, University of Nigeria, Teaching Hospital, Enugu, Nigeria E.O. Modebe 7900319475328460027952 7900319475328460027952 No Department of Radiation Medicine, University of Nigeria, Teaching Hospital, Enugu, Nigeria I.G. Abah 7900319475328460027953 7900319475328460027953 No Department of Radiology, University of Uyo, Akwa Ibom, Nigeria T.O. Nnaji 7900319475328460027954 7900319475328460027954 No Department of Veterinary Surgery and Radiology, University of Nigeria, Nsukka, Nigeria