International Journal of Radiation Research

en Prognostic value of CT perfusion imaging, serum D-D and MMP-9 on hemorrhage transformation after thrombolysis in patients with acute cerebral infarction Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: This study explores the predictive value of Computerized Tomography (CT) perfusion imaging, serum D-dimer (D-D), and serum matrix metalloproteinase-9 (MMP-9) levels for hemorrhagic transformation (HT) in patients with acute cerebral infarction post-thrombolysis. Materials and Methods: Patients with acute cerebral infarction who underwent thrombolytic therapy from February 2021 to February 2022 were included. CT perfusion imaging was conducted within a week post-operation. The study compared CT perfusion parameters and serum markers, analyzing differences and conducting univariate and multivariate analyses to explore their predictive value for HT. Results: No significant differences were found in hypertension, hyperlipidemia, stroke history, mean arterial pressure, fasting blood glucose, and platelet count pre-thrombolysis (P > 0.05). However, infarct diameter ≥ 5 cm and atrial fibrillation were more common in the study group, with higher pre-thrombolysis National Institutes of Health Stroke Scale (NIHSS) score, D-D, and MMP-9 levels (P < 0.05). CT perfusion showed lower relative cerebral blood volume (rCBV, relative cerebral blood flow (rCBF, and higher relative mean transit time (rMTT), relative time to peak (rTTP) in the study group (P < 0.05). D-D and MMP-9 levels were negatively correlated with rCBV, rCBF, and positively with rTTP, CTP integration index (P < 0.05). Conclusion: CT perfusion imaging, serum D-D, and MMP-9 levels are effective predictors of hemorrhagic transformation in acute cerebral infarction patients post-thrombolysis. These findings are valuable for guiding clinical treatment and monitoring.</div> Perfusion imaging, thrombolytic therapy, hemorrhagic transformation, D-dimer, matrix metalloproteinase-9, computed tomography angiography. 711 717 http://ijrr.com/browse.php?a_code=A-10-1-1230&slc_lang=en&sid=1 L. Wang 7900319475328460028055 7900319475328460028055 No Department of Imaging Diagnosis, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China G. Tian 7900319475328460028056 7900319475328460028056 No Department of Imaging Diagnosis, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China H. Zhang 7900319475328460028057 7900319475328460028057 No Department of Imaging Diagnosis, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China J. Chen 7900319475328460028058 7900319475328460028058 No Department of Imaging Diagnosis, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China Z. Sun 7900319475328460028059 7900319475328460028059 No Department of Imaging Diagnosis, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China F. Guo 7900319475328460028060 7900319475328460028060 No Department of Imaging Diagnosis, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China J. Shen shenjie_319@126.com 7900319475328460028061 7900319475328460028061 Yes Department of Imaging Diagnosis, Inner Mongolia Medical University Affiliated Hospital, Hohhot, China