en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The link between the miR-499(rs3746444) gene polymorphism and genetic predisposition to hepatocellular carcinoma (HCC) was thoroughly assessed in this study. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study used Rev-Man 5.41 statistical software to conduct a meta-analysis of case-control studies that investigated the relationship between genetic susceptibility to HCC and the miR-499 gene or the rs3746444 locus polymorphism. The articles were searched in PMC, PubMed, and other databases. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In this analysis, 15 publications were used, with 4901 normal individuals serving as the control group and 3366 HCC patients as members of the experimental group. The findings showed that the risk of getting HCC was higher in those with the AA (95%CI (0.64, 0.94), I2 = 71%, P = 0.009) or AG (95%CI (1.01, 1.40), I2 = 58%, P = 0.04) genotypes. The risk of HCC was minimal when the genotype was GG (95%CI (0.79, 1.50), I2=56%, P = 0.60). A statistical difference was found between the G allele (95%CI (1.13, 1.69), I2 = 60%, P=0.002), while no significant difference was found between the two groups with respect to the A allele (95%CI (0.56, 1.15), I2 = 79%, P = 0.23). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusions: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">There was a strong link between the polymorphism of miR-499 gene and the genetic predisposition to hepatocellular cancer. Therefore, the polymorphism of the miR-499 gene can be utilized as a predictor of liver cancer occurrence, which is highly relevant for the early detection and management of liver cancer.</span></span></span></span></span></span></span></span></span></div> Hepatocellular carcinoma, genetic susceptibility, miR-499 polymorphism, meta-analysis, liver cancer. 733 738 http://ijrr.com/browse.php?a_code=A-10-1-1233&slc_lang=en&sid=1 C. Xiaobo 7900319475328460028073 7900319475328460028073 No Department of Infection, Xiaogan Central Hospital, Xiaogan 432000, China D. Hui 7900319475328460028074 7900319475328460028074 No Department of Oncology, Yan'an Hospital Affiliated to Kunming Medical University, Kunming 650051, China Y. Juan yj87920@126.com 7900319475328460028075 7900319475328460028075 Yes Xiaogan Central Hospital, Xiaogan 432000, China