International Journal of Radiation Research

en Clinical efficacy and safety of laparoscopic radical surgery and radiotherapy for the treatment of early-stage gallbladder cancer Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;">Background: Gallbladder cancer (GBC) is a challenging malignancy with poor prognosis. Although radical cholecystectomy is the accepted surgical approach, the safety and effectiveness of laparoscopic radical surgery and radiotherapy are remained under-studied. Materials and Methods: A single-center, prospective study was conducted from May 2020 to May 2023. One hundred patients diagnosed with early-stage GBC were categorized into two groups: an Intervention Group (n=50) that underwent laparoscopic radical surgery and radiotherapy, and a Control Group (n=50) that received conventional open surgery. Key indicators such as surgical conditions, postoperative rehabilitation, and survival rates were evaluated in both groups. Results: The Intervention Group demonstrated superior surgical outcomes, including a significantly reduced surgical bleeding volume (198.5±23.1 vs. 286.3±18.7 ml, P-value <0.001), shorter operative duration (168.6±64.8 vs. 261.1±55.3 min, P-value <0.001), and smaller incision length (1.1±0.3 vs. 8.2±1.2 cm, P-value <0.001). Postoperatively, the Intervention Group also showed marked improvements in hospital stay duration (7.5±1.4 vs. 9.3±2.9 days, P-value <0.001), time to first ambulation (2.1±0.8 vs. 6.9±1.1 days, P-value <0.001), and gastric function recovery (2.2±0.6 vs. 3.5±1.3 days, P-value <0.001). Complication rates were lower, with abdominal infections observed in 0 cases in the Intervention Group compared to 4 cases (8%) in the Control Group (P-value:0.041). Long-term follow-up indicated a trend toward better 3-year survival rates in the Intervention Group (84% vs 68%, P-value: 0.061). Conclusion: Our findings suggest that laparoscopic radical cholecystectomy is a viable and safe option for treating early-stage GBC, aligning with existing literature that advocates for minimally invasive surgical approaches.</div> Early-stage gallbladder cancer, Laparoscopic radical cholecystectomy, postoperative outcomes, prospective cohort study, surgical Efficacy. 767 770 http://ijrr.com/browse.php?a_code=A-10-1-1238&slc_lang=en&sid=1 A.S. GuiFen Wei 7900319475328460028115 7900319475328460028115 No Hepatobiliary and pancreatic surgery Department, The First People’ Hospital of Tongxiang, Tongxiang, 314500, China H. Ao Dr.med.he1234@gmail.com 7900319475328460028116 7900319475328460028116 Yes Department of Hepatobiliary and Pancreatic Surgery, The Second People's Hospital of Tongxiang, Zhejiang, 314511, China H. Yan 7900319475328460028117 7900319475328460028117 No Hepatobiliary and pancreatic surgery Department, The First People’ Hospital of Tongxiang, Tongxiang, 314500, China J. Huang 7900319475328460028118 7900319475328460028118 No Hepatobiliary and pancreatic surgery Department, The First People’ Hospital of Tongxiang, Tongxiang, 314500, China