en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Oxidative stress-induced tissue damage is a recognized concern linked to electromagnetic radiation (EMR) waves. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">In the present study, we explored the effect of moderate aerobic exercise (AE) on oxidative stress (OS) and cardiomyocyte damage resulting from cell phone EMR in rats. A total of 32 male Wistar rats were randomly allocated into the following groups: control (C), EMR, AE, and EMR+AE. Both EMR+AE and EMR groups were subjected to three hours of daily cell phone EMR (0.9-1.8 GHz) exposure for six weeks, while the AE and EMR+AE groups completed a treadmill AE five days per week. The heart was collected 48 hours after the last AE session to assess OS, histopathological damage, and left ventricular structure. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Tissue sections revealed that the EMR group had more significant heart tissue damage (increased apoptotic cells and collagen deposition) than the C group, and adding AE mitigated the damage (P<0.05). In the EMR group, in comparison to the EMR+AE, C, and AE groups, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) significantly decreased, and the concentration of malondialdehyde (MDA) elevated notably (P < 0.05). Exercise training in both the AE and EMR+AE groups resulted in a notable rise in SOD, CAT, and GPX activity, alongside a notable reduction in MDA concentration in comparison to the EMR group (P < 0.05). </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusions: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">AE is advantageous in mitigating the adverse impacts of EMR emitted from mobile phones on the heart.</span></span></span></span></span></span></span></span></span></span></div> Antioxidants, reactive oxygen species, electromagnetic radiation, heart, oxidative stress. 45 52 http://ijrr.com/browse.php?a_code=A-10-1-1290&slc_lang=en&sid=1 H.A. Akbari 7900319475328460029971 7900319475328460029971 No Department of Exercise Physiology, Faculty of Sports Sciences and Health, University of Tehran, Iran A.A. Gaeini aagaeini@ut.ac.ir 7900319475328460029972 7900319475328460029972 Yes Department of Exercise Physiology, Faculty of Sports Sciences and Health, University of Tehran, Iran M.R. Kordi 7900319475328460029973 7900319475328460029973 No Department of Exercise Physiology, Faculty of Sports Sciences and Health, University of Tehran, Iran A.A. Ravasi A.A. Ravasi 7900319475328460029974 7900319475328460029974 No Department of Exercise Physiology, Faculty of Sports Sciences and Health, University of Tehran, Iran