en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">To examine the usefulness of photon beam radiation therapy for primary cutaneous lymphoma, a phantom experiment was conducted by fabricating and applying an M3 casting type customized bolus by three-dimensional (3D) printing. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Several 3D printers were used to compare output times according to division to reduce the output time of cast-type bolus. The dose distribution and dose verification for each treatment plan of electron beam (6 MeV, 9 MeV) and photon beams (AP/PA, field-in-field 3D conformal radiation therapy [3D CRT], intensity modulated radiotherapy [IMRT]) were analyzed. During photon beam treatment, the inside of the molded bolus was filled with rice and M3 for the experiment. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Compared with the infill type, the split casting type output method improved the output speed of the 3D printer by up to 94.7% and could be applied to patients within 48 h. Moreover, the treatment plan of the photon beam, compared with that of the 9 MeV electron beam, improved the radical dose homogeneity index (rDHI) by 23.0% to 71.3% and the moderate homogeneity index (mDHI) by 7.5% to 18.6% in the planning tumor volume, indicating a more uniform dose distribution. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The difference in treatment plan evaluations between M3 and rice was similar, but in dose delivery, the maximum errors were 3.1% and 6.5%, respectively, indicating that M3 was superior to rice.</span></span></span></span></span></span></span></span></span></span></div> Bolus, 3D printing, Photon beam, Intensity modulated radiotherapy. 69 75 http://ijrr.com/browse.php?a_code=A-10-1-1293&slc_lang=en&sid=1 Y. Won 7900319475328460029982 7900319475328460029982 No Department of Radiation Oncology, Uijeongbu Eulji Medical Center, Eulji University, Gyeonggi-do, South Korea S. Kim ksc@gachon.ac.kr 7900319475328460029983 7900319475328460029983 Yes Department of Radiological Science, Gachon University Medical Campus, Namdong-gu, Incheon, South Korea