International Journal of Radiation Research

en Application value of low-dose computed tomography combined with serum tumor markers in diagnosis of early non-small cell lung cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: We aimed to explore the application value of low-dose computed tomography (LDCT) combined with serum tumor markers in the diagnosis of early non-small cell lung cancer (NSCLC). Materials and Methods: The clinical data of 176 patients suspected of early NSCLC screened from March 2017 to April 2022 were retrospectively collected. The diagnostic values of LDCT, serum tumor markers, and LDCT combined with serum tumor markers for early NSCLC were explored. Results: There were diverse imaging characteristics of early NSCLC, dominated by solid lesions, followed by part-solid nodules, but non-solid nodules were rare. The levels of serum carcinoembryonic antigen, cytokeratin 19 fragment antigen 21-1 and neuron specific enolase in patients with early NSCLC were higher than those in patients with benign lesions (P<0.05). LDCT combined with serum tumor markers had a higher Kappa coefficient than LDCT and serum tumor markers, indicating that it had the highest consistency with pathological diagnosis results (P<0.05). Both the sensitivity and accuracy of LDCT combined with serum tumor markers were higher than those of LDCT and serum tumor markers (P<0.05). Conclusion: LDCT combined with serum tumor markers can significantly improve the diagnostic sensitivity and accuracy for early NSCLC and the consistency with pathological diagnosis results, and effectively reduce misdiagnosis and missed diagnosis.</div> Computed tomography, early diagnosis, non-small cell lung cancer, serum, tumor markers. 77 81 http://ijrr.com/browse.php?a_code=A-10-1-1294&slc_lang=en&sid=1 R. Xu 7900319475328460029984 7900319475328460029984 No Department of Oncology,Affiliated People's Hospital of Jiangsu University, Zhenjiang City, jiangsu, Province China W. Xu 7900319475328460029985 7900319475328460029985 No Department of Oncology,Affiliated People's Hospital of Jiangsu University, Zhenjiang City, jiangsu, Province China D. Liu 7900319475328460029986 7900319475328460029986 No Department of Thoracic Surgery, Shandong Public Health Clinical Center (Shandong Provincial Chest Hospital), Shandong Province, China S. Pan 7900319475328460029987 7900319475328460029987 No Department of Laboratory Medicine, Shengli Oilfield Central Hospital, Shandong Province, China J. Zhu 7900319475328460029988 7900319475328460029988 No Department of Thoracic Surgery, Shandong Public Health Clinical Center (Shandong Provincial Chest Hospital), Shandong Province, China Y. Shen 7900319475328460029989 7900319475328460029989 No Department of Respiratory Medicine, Shandong Public Health Clinical Center (Shandong Provincial Chest Hospital), Shandong Province, China C. Wang qie85615604@163.com 7900319475328460029990 7900319475328460029990 Yes Department of Thoracic Surgery, Shandong Public Health Clinical Center (Shandong Provincial Chest Hospital), Shandong Province, China H. Shen Shenhuiling0826@163.com 7900319475328460029991 7900319475328460029991 No Department of Oncology,Affiliated People's Hospital of Jiangsu University, Zhenjiang City, jiangsu, Province China