International Journal of Radiation Research

en Feasibility study of an automatic injection plan for coronary computed tomography angiography using 80 kilovolt and very low iodine dose Radiation Biology Radiation Biology تحقيق بديع Original Research Background: To explore the feasibility of using various ultra-low contrast flow rates on the coronary CTA (CCTA) when the tube voltage is set at 80KV automatically on 3rd-generation dual-source CT. Materials and Methods: A total of 180 patients with suspected coronary atherosclerotic disease were randomly divided into two groups, each subdivided into seven BMI-based subgroups (≤ 25, 25-26, 26-27, 27-28, 28-29, 29-30, > 30). The experimental group (A) used individualized injection rates (2.8-3.4 ml/s) with 350 mg I/ml contrast agent based on BMI, with a fixed injection time of 10s. The control group (B) used a fixed injection rate of 4.0 ml/s and a fixed injection time of 12s. Both groups employed prospective ECG-gated scanning. Image quality, effective radiation dose, and contrast agent dosage were compared using the Student's t-test. Results: In Group B, the coronary artery CT value exceeded the optimal diagnostic range (300-450 HU) recommended by experts. Group A had significantly lower CT values, SNR, and CNR compared to Group B (P < 0.05), but the enhancement in Group A was closer to the optimal diagnostic range. There was no significant difference in subjective image scores between the groups (P > 0.05), with consistent scoring between two directors (ICC: 0.612-0.852). Both groups had similar effective doses (P > 0.05). The contrast agent dosage in Group A was significantly lower than in Group B (P < 0.05). Conclusion: The optimized contrast injection scheme can significantly reduce the amount of contrast agent and obtain better image quality.   <div style="text-align: justify;">Background: To explore the feasibility of using various ultra-low contrast flow rates on the coronary CTA (CCTA) when the tube voltage is set at 80KV automatically on 3rd-generation dual-source CT. Materials and Methods: A total of 180 patients with suspected coronary atherosclerotic disease were randomly divided into two groups, each subdivided into seven BMI-based subgroups (≤ 25, 25-26, 26-27, 27-28, 28-29, 29-30, > 30). The experimental group (A) used individualized injection rates (2.8-3.4 ml/s) with 350 mg I/ml contrast agent based on BMI, with a fixed injection time of 10s. The control group (B) used a fixed injection rate of 4.0 ml/s and a fixed injection time of 12s. Both groups employed prospective ECG-gated scanning. Image quality, effective radiation dose, and contrast agent dosage were compared using the Student's t-test. Results: In Group B, the coronary artery CT value exceeded the optimal diagnostic range (300-450 HU) recommended by experts. Group A had significantly lower CT values, SNR, and CNR compared to Group B (P < 0.05), but the enhancement in Group A was closer to the optimal diagnostic range. There was no significant difference in subjective image scores between the groups (P > 0.05), with consistent scoring between two directors (ICC: 0.612-0.852). Both groups had similar effective doses (P > 0.05). The contrast agent dosage in Group A was significantly lower than in Group B (P < 0.05). Conclusion: The optimized contrast injection scheme can significantly reduce the amount of contrast agent and obtain better image quality.</div> Coronary angiography, low tube voltage, radiation dose, contrast media injection plan. 135 140 http://ijrr.com/browse.php?a_code=A-10-1-1302&slc_lang=en&sid=1 Y. Yang 7900319475328460029534 7900319475328460029534 No Department of Radiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China S. Ge 7900319475328460029535 7900319475328460029535 No Department of Radiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China Y. Chen 7900319475328460029536 7900319475328460029536 No Department of Radiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China C.P. Jing jcp880108@163.com 7900319475328460029537 7900319475328460029537 Yes Department of Radiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China