International Journal of Radiation Research

en Predicting prostate cancer radiotherapy complications: An integrated approach using radiomics, dosiomics, and machine learning Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: We aimed to develop a robust prognostic model for assessing the risk of complications associated with radiotherapy in prostate cancer patients using radiomics and dosiomics feature and machine learning. Materials and Methods: A cohort of 60 patients undergoing pelvic radiation therapy was analyzed. The patients’ radiomics and dosiomics features were extracted from segmented bladder and rectum regions in CT images, as well as 3D dose distribution data, respectively. Classifier algorithms, such as eXtreme Gradient Boosting (XGBoost), Decision Tree (DT), Support Vector Machines (SVM), K-Nearest Neighbor (KNN), Logistic Regression (LR), Random Forest (RF), and Multilayer Perceptron (MLP) were used for prediction modeling. A 5-fold cross-validation method was used to evaluate the predictive classification of patients with and without proctitis and cystitis. The area under the receiver operating characteristic curve (AUC) was used for comparing models’ performance, as well assessing their specificity and accuracy metrics. Results: Various combinations of feature selection and classifier algorithms evaluated on both training and test datasets revealed that for bladder toxicity, the Relief+KNN dosiomics model, Boruta+SVM radiomics model, and the combined radiomics and dosiomics model with ANOVA+XGBoost show the highest AUCs of 0.76, 0.68, and 0.67, respectively. Regarding the rectal toxicity, the best-performing models were Boruta+KNN for dosiomics (AUC 0.83), ANOVA+RF for radiomics (AUC 0.72), and ANOVA+XGBoost for the combined radiomics and dosiomics (AUC 0.71). Conclusion: Our study demonstrated the effectiveness of diverse algorithms leveraging quantitative features extracted from CT imaging and 3D dose distribution data in predicting post-radiotherapy complications in prostate cancer patients.</div> Prostate cancer, radiotherapy, radiomics, dosiomics, machine-learning. 239 244 http://ijrr.com/browse.php?a_code=A-10-1-1316&slc_lang=en&sid=1 E. Sadati 7900319475328460029790 7900319475328460029790 No Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran B. Hashemi bhashemi@modares.ac.ir 7900319475328460029791 7900319475328460029791 Yes Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran S.R. Mahdavi 7900319475328460029792 7900319475328460029792 No Department of Medical Physics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran A. Nikoufar 7900319475328460029793 7900319475328460029793 No Department of Radiation Oncology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran H. Abdollahi 7900319475328460029794 7900319475328460029794 No Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada