International Journal of Radiation Research

en Evaluation of imaging diagnostics in dizziness induced by cerebral small vessel disease: A focus on transcranial Doppler and CT Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;">Background: This study aims to evaluate the therapeutic efficacy of hyperbaric oxygen (HBO) as adjuvant therapy for patients with cerebral small vessel disease (CSVD) related dizziness and to assess the impact of this treatment on diagnostic indicators from both transcranial Doppler (TCD) and computed tomography (CT). Materials and Methods: A prospective randomized controlled study was conducted from January 2019 to December 2023, including 200 patients with CSVD related dizziness. They were randomly assigned to either the HBO group or the control group. The control group received betahistine mesylate tablets, while the HBO group received HBO in addition to the control group treatment. Various parameters including Dizziness Handicap Inventory (DHI) scores, cerebral artery blood flow velocity (Vm), resistance index (RI), pulsatility index (PI), cystatin (Cys), homocysteine (HCY), hypersensitive c-reactive protein (hs-CRP) levels, and CT imaging for grading cerebral white matter degeneration were assessed before and after treatment. Results: After treatment, DHI scores in both groups decreased significantly, with the HBO group showing greater improvement compared to the control group. Hemodynamic parameters (Vm, RI, PI) improved significantly in both groups, with greater improvements seen in the HBO group. White matter lesion grading and levels of Cys, HCY, and hs-CRP were significantly lower in the HBO group post-treatment compared to the control group. Conclusions: HBO as adjuvant therapy demonstrates significant therapeutic benefits for CSVD related dizziness. It effectively alleviates symptoms, improves hemodynamic parameters, enhances white matter lesion assessment outcomes, and promotes neurological function recovery.</div> Cerebral small vessel disease, dizziness, transcranial Doppler, computed tomography, diagnostic imaging. 249 254 http://ijrr.com/browse.php?a_code=A-10-1-1320&slc_lang=en&sid=1 Y. Wei 7900319475328460029931 7900319475328460029931 No Department of Neurology, Shanghai Construction Engineering Hospital, Shanghai, China Q. Wang 7900319475328460029932 7900319475328460029932 No Department of Neurology, Shanghai Construction Engineering Hospital, Shanghai, China J. Yang 7900319475328460029933 7900319475328460029933 No Department of Neurology, Shanghai Construction Engineering Hospital, Shanghai, China