en Radiation Biology Radiation Biology مقاله مروری Review article <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="language:en-US">This review article explores the key targets and mechanisms of radiotherapy (RT)-induced gastrointestinal mucositis (RIGIM) development and progression. RIGIM is a frequent and potentially disabling side effect of radiation therapy, impacting the mucosal lining of the gastrointestinal tract. The pathophysiology of RIGIM is complex, involving oxidative stress, inflammatory pathways, DNA damage, changes in the gut microbiota, and disruption of the mucosal barrier&rsquo;s integrity. The clinical presentation of RIGIM varies, ranging from mild inflammation to severe ulceration, significantly impacting patients&rsquo; quality of life, nutrition, and treatment adherence. This article discusses the risk factors, symptoms, and clinical manifestations of RIGIM, as well as current and potential therapeutic strategies. These strategies include pharmacological interventions, microbiome modulation, and supportive care, aimed at preventing, mitigating, or treating RIGIM and ultimately improving the lives of cancer patients undergoing RT.</span></span></span></span></span></span></span></div> Gastrointestinal tract, mucositis, radiation, ionizing, inflammation, gastrointestinal microbiome, radiotherapy. 771 782 http://ijrr.com/browse.php?a_code=A-10-1-1396&slc_lang=en&sid=1 L. Shi 7900319475328460031955 7900319475328460031955 No Department of Gastroenterology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266042, China X. Sun 7900319475328460031956 7900319475328460031956 No Department of Gastroenterology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266042, China X. Wang 7900319475328460031957 7900319475328460031957 No Department of General Surgery, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266042, China H. Zhao zhaohong1968qd@163.com 7900319475328460031958 7900319475328460031958 Yes Department of Gastroenterology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266042, China