en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Globally, gastric cancer (GC) continues to be a primary driver of cancer deaths, as delayed diagnoses frequently lead to unfavorable clinical outcomes. Accurate preoperative assessment is critical for optimizing treatment strategies and enhancing patient outcomes. This research analyzed the preoperative evaluation value of multi-slice spiral computed tomography (MSCT) perfusion imaging in GC. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Material and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A cohort of 112 GC patients was recruited between January 2022 and April 2024 for quantification of MSCT perfusion metrics, including blood flow (BF), blood volume (BV), permeability surface (PS), and mean transit time (MTT). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Advanced-stage GC exhibited significantly higher BF, BV, and PS than early-stage disease (P<0.05). TNM stage progression (Ia+Ib &rarr; III+IIIa &rarr; III+IV) correlated with increasing BF, BV, and PS (P<0.05), while tumor location showed no significant parameter differences. Well-differentiated tumors had higher BF and PS but lower MTT than poorly differentiated cases (P<0.05). Patients without lymph node metastasis (LNM) or distant metastasis demonstrated reduced perfusion parameters, with BF and PS being statistically lower in non-metastatic groups (P<0.05). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion:</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> These findings suggest that MSCT perfusion imaging effectively reflects hemodynamic changes and provides valuable insights into tumor staging, differentiation, and metastasis, supporting its clinical utility in preoperative GC evaluation.</span></span></span></span></span></span></span></span></span></div> Stomach neoplasms, multidetector computed tomography, perfusion imaging, preoperative period, neoplasm staging, hemodynamics. 889 894 http://ijrr.com/browse.php?a_code=A-10-1-1411&slc_lang=en&sid=1 F. Peng 7900319475328460032326 7900319475328460032326 No Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China J. Song 7900319475328460032327 7900319475328460032327 No Department of Radiology, the Second Affiliated Hospital Of Hainan Medical University, Hainan Haikou 570311, China Y. Zhang 7900319475328460032328 7900319475328460032328 No Department of Breast Armor Surgery, the Second Affiliated Hospital Of Hainan Medical University Hainan Haikou 570311, China Q. Peng jack6558@163.com 7900319475328460032329 7900319475328460032329 Yes Large aperture CT room, Shandong Cancer Hospital, Jinan City, Shandong Province, 250117 China