International Journal of Radiation Research

en Dosimetric and biological evaluation of respiratory motion effects on dose distribution in lung cancer SIB-SBRT Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Simultaneous integrated boost-stereotactic body radiotherapy (SIB-SBRT) is an effective technique for lung cancer treatment but is significantly affected by respiratory motion. This study employed a four-dimensional (4D) dose calculation method to evaluate the impact of respiratory motion on dose delivery. Materials and Methods: Retrospective analysis was performed on data from 17 lung cancer patients who underwent four-dimensional computed tomography (4DCT). Volumetric modulated arc therapy (VMAT) plans, referred to as the original plans, were designed with dose prescriptions of 6 Gy per fraction for the internal target volume (ITV) and 5 Gy per fraction for the planning target volume (PTV). Control points (CPs) and monitor units (MUs) from the original plans were mapped onto ten respiratory phases of the 4DCT to generate sub-plans. These sub-plans were combined to form a 4D dose plan, followed by evaluation of physical and biological dose effects. Results: Compared to the original plans, respiratory motion reduced V100 by 1.4% for the ITV and 3.5% for the PTV. Additionally, it decreased the tumor control probability (TCP) by 0.1% for the ITV and 4.2% for the PTV. Gamma analysis revealed hot spots at the target periphery and cold spots within the target. Conclusion: Respiratory motion has a greater impact on PTV than ITV in SIB-SBRT. Dose deviations and distribution should be considered to enhance treatment accuracy.</div> Lung neoplasms, stereotactic body radiotherapy, four-dimensional computed tomography, respiratory motion. 927 934 http://ijrr.com/browse.php?a_code=A-10-1-1417&slc_lang=en&sid=1 L. Liu 7900319475328460032352 7900319475328460032352 No University of Science and Technology of China, Hefei, 230026, Anhui, China Z. Fei 7900319475328460032353 7900319475328460032353 No Department of Radiation Oncology, The 901st Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army, Hefei, 230031, Anhui, China X. Pei 7900319475328460032354 7900319475328460032354 No Technology Development Department, Anhui Wisdom Technology Company Limited, Hefei, 230000, Anhui, China Q. Ren 7900319475328460032355 7900319475328460032355 No Technology Development Department, Anhui Wisdom Technology Company Limited, Hefei, 230000, Anhui, China J. Li 7900319475328460032356 7900319475328460032356 No University of Science and Technology of China, Hefei, 230026, Anhui, China X. Cui xlcui@cmpt.ac.cn 7900319475328460032357 7900319475328460032357 Yes Hefei Cancer Hospital of CAS, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui, China H. Wang wanghz@hfcas.ac.cn 7900319475328460032358 7900319475328460032358 No University of Science and Technology of China, Hefei, 230026, Anhui, China