en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study aimed to evaluate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in improving self-efficacy, quality of life, and mental health outcomes in patients with lung cancer undergoing radiotherapy. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">A randomized controlled trial was conducted involving 60 patients diagnosed with lung cancer and scheduled to receive radiotherapy between January 2024 and February 2025. Patients were randomly assigned to either the intervention group (IG, n=30), which received MBCT in addition to standard oncological care, or the control group (CG, n=30), which received standard oncological care alone. The MBCT program was delivered over eight weekly sessions during the radiotherapy course. Outcome measures included quality of life (QoL), self-efficacy (SE), cancer-related fatigue, and levels of depression and anxiety. Assessments were conducted at baseline, one day after completing radiotherapy, and seven days post-treatment. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Compared to baseline, patients in the intervention group showed significant improvements in QoL, self-relaxation, positive attitude, decision-making confidence, and overall self-efficacy (P<0.05). These improvements were significantly greater than those observed in the control group at both follow-up points. Furthermore, the intervention group exhibited markedly reduced symptoms of depression, anxiety, and cancer-related fatigue-particularly emotional and cognitive fatigue-seven days post-treatment (P<0.05). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">MBCT significantly enhances self-efficacy and mental health outcomes in lung cancer patients undergoing radiotherapy. These findings support the integration of MBCT as a complementary psychosocial intervention in radiotherapy care to improve patients&rsquo; psychological resilience and quality of life.</span></span></span></span></span></span></span></span></span></div> Mindfulness-based cognitive therapy (MBCT), lung cancer, radiotherapy, self-efficacy, mental health, quality of life. 1017 1022 http://ijrr.com/browse.php?a_code=A-10-1-1429&slc_lang=en&sid=1 B. Xie 18058445771@163.com 7900319475328460032528 7900319475328460032528 Yes Zhejiang 1Class 2, Nursing, 21st Batch, Equal Academic Qualification Program, Zhejiang Chinese Medical University, Hangzhou, 310002, Zhejiang Province, China X. Ma 7900319475328460032529 7900319475328460032529 No Department of Medical Engineering, Hangzhou First People's Hospital, Hangzhou, 310000, Zhejiang Province, China