Background: This study aimed to investigate the radiation hazard indices from sand samples of  Ma’rib Governorate in Yemen, where the majority of oil and gas facilities are installed. Methods and Materials: Thirty five samples of desert sand from Ma’rib Governorate in Yemen were collected and tested their radiation hazard indices by using High Purity Germanium (HPGe) detector. Results: Based on the measurement of the concentrations of ²²⁶Ra, ²³²Th, and ⁴⁰K, the radium equivalent activity (Ra_eq), the activity concentration index (I_γ), the external hazard index (H_ex) and the internal hazard index (H_in) were all calculated.  Also, the absorbed dose rate in Air (ADR) and the annual effective dose (AED) are calculated. Conclusions: Comparing the practically attained results with internationally permissible values, it was found that most of the radiological parameters, including the radiation hazard indices of the studied samples, fall within the world's permissible limits and don't expose risks to the human beings and environments.