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Establishment of nomogram prediction model for distant metastasis of nasopharyngeal carcinoma after radiotherapy
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Y. Fan   , M. Hui , F. Li , Y. Chen , J. Liu , C. Huang |
| Department of ENT, Affiliated Hospital Of Guangdong Medical University, Zhenjiang, 524001, China , Huiminglang@126.com |
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Abstract: (434 Views) |
Background: The research aims to construct a nomograph model for predicting distant metastasis of nasopharyngeal carcinoma after radiotherapy, and to evaluate the differentiation and consistency of the model. Materials and Methods: 292 nasopharyngeal carcinoma patients are selected and broken into a modeling group (204 cases) and a validation group (88 cases). The modeling group patients are further divided into a distant metastasis group (n=45) and a non-distant metastasis group (n=159). Logistic regression analysis is used to analyze the risk factors for distant metastasis of nasopharyngeal carcinoma after radiotherapy. Radiation therapy is performed on each group of patients and their lactate dehydrogenase, serum albumin, carcinoembryonic antigen are compared. Results: The proportion of age ≥ 60 years old, lymph node cystic invasion, laryngeal lymph node metastasis, T3-T4 staging, and N2-N3 staging in the distant metastasis group were higher than those in the non-distant metastasis group (P<0.05). Multiple logistic regression analysis denoted that age ≥ 60 years old, lymph node cystic invasion, laryngeal lymph node metastasis, T3-T4 stage, N2-N3 stage were risk factors for distant metastasis of nasopharyngeal carcinoma after radiotherapy (P<0.05). The Hosmer Limeshow goodness of fit test showed that the modeling group 2=5.489, P=0.601; Validation group 2=5.231, P=0.733. The areas under the receiver operating characteristic curves of the modeling group and the validation group were 0.828 and 0.822, respectively. Conclusion: The model constructed in this study for forecasting the risk of distant metastasis of nasopharyngeal carcinoma after radiotherapy has high prediction accuracy, good consistency, differentiation, and clinical applicability. |
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| Keywords: Nasopharyngeal carcinoma, radiotherapy, distant metastasis, nomogram, prediction model. |
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Full-Text [PDF 712 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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| References |
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Fan Y, Hui M, Li F, Chen Y, Liu J, Huang C. Establishment of nomogram prediction model for distant metastasis of nasopharyngeal carcinoma after radiotherapy. Int J Radiat Res 2024; 22 (2) :373-378 URL: http://ijrr.com/article-1-5442-en.html
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