Clinical analysis of gamma knife radiosurgery for pituitary adenomas

Shan, J.; Wen, Y.; Guo, Y.

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Volume 23, Issue 1 (1-2025)

Int J Radiat Res 2025, 23(1): 61-68

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Clinical analysis of gamma knife radiosurgery for pituitary adenomas

J. Shan

, Y. Wen

, Y. Guo

Special Examination Department, Shandong Daizhuang Hospital, JiNing City, Shandong, China , Shanaaa0410@163.com

Abstract: (393 Views)

To evaluate the efficacy and safety of Gamma Knife radiosurgery in the treatment of pituitary adenomas. Materials and Methods: A retrospective analysis was conducted on 123 patients with pituitary adenomas who underwent Gamma Knife radiosurgery at Shandong Daizhuang hospital. All patients were followed up for 12 months post-treatment and complete follow-up data were obtained. Follow-up data included records of disease progression (medical history and physical examination changes), imaging and endocrine follow-up results at re-examination. Univariate analysis was performed to identify factors affecting tumor control and post-treatment complications, and factors with statistical significance (P <0.05) were subjected to multivariate analysis. Results: Clinical data of 123 patients with pituitary adenomas were included in this study, with 51 patients in the postoperative group who had previously undergone surgical treatment, and 72 patients who were treated first with Gamma Knife radiosurgery. Except for age, there were no statistically significant differences in baseline data between the two groups. Tumor volume [P=0.034, odds ratio (OR)=1.071, 95% confidence interval (CI): 0.121-5.206] and tumor invasion (P=0.005, OR=0.233, 95% CI: 0.202-0.392) were predictive factors for tumor progression. The results of the 1-year follow-up showed no statistically significant difference in efficacy between patients with pituitary adenomas who had previously undergone surgical treatment and those who were first treated with Gamma Knife radiosurgery. Conclusion: Gamma Knife radiosurgery is an effective treatment option for patients with pituitary adenomas, regardless of whether they have previously undergone surgical treatment.

Keywords: Gamma Knife, radiosurgery, pituitary adenoma, risk factors, regression analysis.

Full-Text [PDF 652 kb] (72 Downloads)

Type of Study: Original Research | Subject: Radiation Biology

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Shan J, Wen Y, Guo Y. Clinical analysis of gamma knife radiosurgery for pituitary adenomas. Int J Radiat Res 2025; 23 (1) :61-68
URL: http://ijrr.com/article-1-5946-en.html

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