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Application value of low-dose computed tomography combined with serum tumor markers in diagnosis of early non-small cell lung cancer
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R. Xu   , W. Xu , D. Liu , S. Pan , J. Zhu , Y. Shen , C. Wang , H. Shen |
| Department of Thoracic Surgery, Shandong Public Health Clinical Center (Shandong Provincial Chest Hospital), Shandong Province, China , qie85615604@163.com |
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Abstract: (212 Views) |
Background: We aimed to explore the application value of low-dose computed tomography (LDCT) combined with serum tumor markers in the diagnosis of early non-small cell lung cancer (NSCLC). Materials and Methods: The clinical data of 176 patients suspected of early NSCLC screened from March 2017 to April 2022 were retrospectively collected. The diagnostic values of LDCT, serum tumor markers, and LDCT combined with serum tumor markers for early NSCLC were explored. Results: There were diverse imaging characteristics of early NSCLC, dominated by solid lesions, followed by part-solid nodules, but non-solid nodules were rare. The levels of serum carcinoembryonic antigen, cytokeratin 19 fragment antigen 21-1 and neuron specific enolase in patients with early NSCLC were higher than those in patients with benign lesions (P<0.05). LDCT combined with serum tumor markers had a higher Kappa coefficient than LDCT and serum tumor markers, indicating that it had the highest consistency with pathological diagnosis results (P<0.05). Both the sensitivity and accuracy of LDCT combined with serum tumor markers were higher than those of LDCT and serum tumor markers (P<0.05). Conclusion: LDCT combined with serum tumor markers can significantly improve the diagnostic sensitivity and accuracy for early NSCLC and the consistency with pathological diagnosis results, and effectively reduce misdiagnosis and missed diagnosis. |
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| Keywords: Computed tomography, early diagnosis, non-small cell lung cancer, serum, tumor markers. |
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Full-Text [PDF 664 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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