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Feasibility study of an automatic injection plan for coronary computed tomography angiography using 80 kilovolt and very low iodine dose
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Y. Yang   , S. Ge , Y. Chen , C.P. Jing |
| Department of Radiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian 223300, China , jcp880108@163.com |
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Abstract: (285 Views) |
Background: To explore the feasibility of using various ultra-low contrast flow rates on the coronary CTA (CCTA) when the tube voltage is set at 80KV automatically on 3rd-generation dual-source CT. Materials and Methods: A total of 180 patients with suspected coronary atherosclerotic disease were randomly divided into two groups, each subdivided into seven BMI-based subgroups (≤ 25, 25-26, 26-27, 27-28, 28-29, 29-30, > 30). The experimental group (A) used individualized injection rates (2.8-3.4 ml/s) with 350 mg I/ml contrast agent based on BMI, with a fixed injection time of 10s. The control group (B) used a fixed injection rate of 4.0 ml/s and a fixed injection time of 12s. Both groups employed prospective ECG-gated scanning. Image quality, effective radiation dose, and contrast agent dosage were compared using the Student's t-test. Results: In Group B, the coronary artery CT value exceeded the optimal diagnostic range (300-450 HU) recommended by experts. Group A had significantly lower CT values, SNR, and CNR compared to Group B (P < 0.05), but the enhancement in Group A was closer to the optimal diagnostic range. There was no significant difference in subjective image scores between the groups (P > 0.05), with consistent scoring between two directors (ICC: 0.612-0.852). Both groups had similar effective doses (P > 0.05). The contrast agent dosage in Group A was significantly lower than in Group B (P < 0.05). Conclusion: The optimized contrast injection scheme can significantly reduce the amount of contrast agent and obtain better image quality.
Background: To explore the feasibility of using various ultra-low contrast flow rates on the coronary CTA (CCTA) when the tube voltage is set at 80KV automatically on 3rd-generation dual-source CT. Materials and Methods: A total of 180 patients with suspected coronary atherosclerotic disease were randomly divided into two groups, each subdivided into seven BMI-based subgroups (≤ 25, 25-26, 26-27, 27-28, 28-29, 29-30, > 30). The experimental group (A) used individualized injection rates (2.8-3.4 ml/s) with 350 mg I/ml contrast agent based on BMI, with a fixed injection time of 10s. The control group (B) used a fixed injection rate of 4.0 ml/s and a fixed injection time of 12s. Both groups employed prospective ECG-gated scanning. Image quality, effective radiation dose, and contrast agent dosage were compared using the Student's t-test. Results: In Group B, the coronary artery CT value exceeded the optimal diagnostic range (300-450 HU) recommended by experts. Group A had significantly lower CT values, SNR, and CNR compared to Group B (P < 0.05), but the enhancement in Group A was closer to the optimal diagnostic range. There was no significant difference in subjective image scores between the groups (P > 0.05), with consistent scoring between two directors (ICC: 0.612-0.852). Both groups had similar effective doses (P > 0.05). The contrast agent dosage in Group A was significantly lower than in Group B (P < 0.05). Conclusion: The optimized contrast injection scheme can significantly reduce the amount of contrast agent and obtain better image quality. |
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| Keywords: Coronary angiography, low tube voltage, radiation dose, contrast media injection plan. |
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Type of Study: Original Research |
Subject:
Radiation Biology
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| References |
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Yang Y, Ge S, Chen Y, Jing C. Feasibility study of an automatic injection plan for coronary computed tomography angiography using 80 kilovolt and very low iodine dose. Int J Radiat Res 2025; 23 (1) :135-140 URL: http://ijrr.com/article-1-5984-en.html
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