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Ultrasound measurement of sheath nerve diameter for guided drug therapy for severe craniocerebral injury
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Y. Fan   , J. Niu , Q. Lu |
| Department of Critical Care Medicine, Shaoxing Second Hospital, Zhejiang University , FanYaoq998@hotmail.com |
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Abstract: (57 Views) |
Background: Severe traumatic brain injured (STBI) is a leading reason for death and long-term disabilities, and improved real-time management of intracranial pressure (ICP) is necessary. This study evaluated the efficacy of drug therapy with ultrasound-guided in patients with STBI by measuring optic nerves sheath diameters (ONSD). Materials and Methods: This retrospective case-control study involved 263 patients with STBI who were treated between March 2019 and June 2021. Patients were categorized in an ultrasound group (n=125), which received ONSD-guided therapy, and a regular group (n=138), which received conventional treatment. Neurogenic and inflammatory markers, clinical scales, and functional recovery metrics were assessed. Results: The ultrasound group showed remarkably improved early-treatment outcomes, such as decreased abnormal breathing (27.20% vs. 40.58%, P=0.022) and lower ICP (54.40% < 350 mmHg vs. 40.58%, P=0.025). This group also showed increased neurogenic factors (brain-derived neurotrophic factors (BDNF) and nerve growth factors (NGF)) and notable decreases in inflammatory indicators like tumor necrosis factor α (TNF-α) (P<0.05). Post-treatment neurological scores were better in the ultrasound group (National Institutes of Health Stroke Scale (NIHSS): 18.32 vs. 18.96 (P=0.018); Glasgow Coma Scale (GCS): 11.19 vs. 10.54 (P=0.007)). Functional assessments (Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS), Modified Barthel Indexs (MBI)) and quality of life (Simplified Form of Health Questionnaire-36 (SF-36)) indices also favored the ultrasound group. Conclusion: Ultrasound-guided ONSD measurement enhances real-time ICP management in drug therapy for patients with STBI. The measurement has positive effects on neurogenic and inflammatory profiles, functional recoveries, and quality of life. |
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| Keywords: Severe traumatic brain injury, ultrasound measurement, optic nerve sheath diameter, neurogenic markers, functional recovery. |
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Full-Text [PDF 1087 kb]
(30 Downloads)
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Type of Study: Short Report |
Subject:
Radiation Biology
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